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On stimulating fungi $Pleurotus~ostreatus$ with Cortisol
arXiv - CS - Emerging Technologies Pub Date : 2021-06-01 , DOI: arxiv-2106.00837
Mohammad Mahdi Dehshibi, Alessandro Chiolerio, Anna Nikolaidou, Richard Mayne, Antoni Gandia, Mona Ashtari, Andrew Adamatzky

Fungi cells are capable of sensing extracellular cues through reception, transduction and response systems which allow them to communicate with their host and adapt to their environment. They display effective regulatory protein expressions which enhance and regulate their response and adaptation to a variety of triggers such as stress, hormones, light, chemicals and host factors. In our recent studies, we have shown that $Pleurotus$ oyster fungi generate electrical potential impulses in the form of spike events as a result of their exposure to environmental, mechanical and chemical triggers, demonstrating that it is possible to discern the nature of stimuli from the fungi electrical responses. Harnessing the power of fungi sensing and intelligent capabilities, we explored the communication protocols of fungi as reporters of human chemical secretions such as hormones, addressing the question if fungi can sense human signals. We exposed $Pleurotus$ oyster fungi to cortisol, directly applied to a surface of a hemp shavings substrate colonised by fungi, and recorded the electrical activity of fungi. The response of fungi to cortisol was also supplementary studied through the application of X-ray to identify changes in the fungi tissue, where receiving cortisol by the substrate can inhibit the flow of calcium and, in turn, reduce its physiological changes. This study could pave the way for future research on adaptive fungal wearables capable for detecting physiological states of humans and biosensors made of living fungi.

中文翻译:

用皮质醇刺激真菌 $Pleurotus~ostreatus$

真菌细胞能够通过接收、转导和反应系统感知细胞外信号,从而使它们能够与宿主交流并适应环境。它们显示出有效的调节蛋白表达,可增强和调节它们对各种触发因素(如压力、激素、光、化学物质和宿主因素)的反应和适应。在我们最近的研究中,我们已经表明 $Pleurotus$ 牡蛎真菌由于暴露于环境、机械和化学触发器而以尖峰事件的形式产生电势脉冲,这表明可以从真菌的电反应。利用真菌感应和智能能力的力量,我们探索了真菌作为人类化学分泌物(如激素)的报告者的通信协议,解决了真菌是否可以感知人类信号的问题。我们将 $Pleurotus$ 牡蛎真菌暴露于皮质醇,直接应用于真菌定植的大麻刨花基质表面,并记录真菌的电活动。真菌对皮质醇的反应也通过应用 X 射线来补充研究,以识别真菌组织的变化,其中基质接受皮质醇可以抑制钙的流动,进而减少其生理变化。这项研究可以为未来研究能够检测人类生理状态的自适应真菌可穿戴设备和由活真菌制成的生物传感器铺平道路。我们将 $Pleurotus$ 牡蛎真菌暴露于皮质醇,直接应用于真菌定植的大麻刨花基质表面,并记录真菌的电活动。真菌对皮质醇的反应也通过应用 X 射线来补充研究,以识别真菌组织的变化,其中基质接受皮质醇可以抑制钙的流动,进而减少其生理变化。这项研究可以为未来研究能够检测人类生理状态的自适应真菌可穿戴设备和由活真菌制成的生物传感器铺平道路。我们将 $Pleurotus$ 牡蛎真菌暴露于皮质醇,直接应用于真菌定植的大麻刨花基质表面,并记录真菌的电活动。真菌对皮质醇的反应也通过应用 X 射线来补充研究,以识别真菌组织的变化,其中基质接受皮质醇可以抑制钙的流动,进而减少其生理变化。这项研究可以为未来研究能够检测人类生理状态的自适应真菌可穿戴设备和由活真菌制成的生物传感器铺平道路。真菌对皮质醇的反应也通过应用 X 射线来补充研究,以识别真菌组织的变化,其中基质接受皮质醇可以抑制钙的流动,进而减少其生理变化。这项研究可以为未来研究能够检测人类生理状态的自适应真菌可穿戴设备和由活真菌制成的生物传感器铺平道路。真菌对皮质醇的反应也通过应用 X 射线来补充研究,以识别真菌组织的变化,其中基质接受皮质醇可以抑制钙的流动,进而减少其生理变化。这项研究可以为未来研究能够检测人类生理状态的自适应真菌可穿戴设备和由活真菌制成的生物传感器铺平道路。
更新日期:2021-06-03
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