Objective:

Shared genetic mechanisms have been hypothesized to explain the comorbidity between ADHD and asthma. To evaluate their genetic overlap, we relied on data from the 1982 Pelotas birth cohort to test the association between polygenic risk scores (PRSs) for ADHD (ADHD-PRSs) and asthma, and PRSs for asthma (asthma-PRSs) and ADHD.

Method:

We analyzed data collected at birth, 2, 22, and 30 years from 3,574 individuals.

Results:

Subjects with ADHD had increased risk of having asthma (OR 1.92, 95% CI 1.01–3.66). The association was stronger for females. Our results showed no evidence of association between ADHD-PRSs and asthma or asthma-PRSs and ADHD. However, an exploratory analysis suggested that adult ADHD might be genetically associated with asthma.

Conclusion:

Our results do not support a shared genetic background between both conditions. Findings should be viewed in light of important limitations, particularly the sample size and the self-reported asthma diagnosis. Studies in larger datasets are required to better explore the genetic overlap between adult ADHD and asthma.

中文翻译：

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ADHD 和哮喘的多基因风险评分之间的关​​联：出生队列调查

客观的：

已经假设共有的遗传机制可以解释 ADHD 和哮喘之间的共病。为了评估它们的遗传重叠，我们依靠来自 1982 年 Pelotas 出生队列的数据来测试 ADHD (ADHD-PRS) 和哮喘的多基因风险评分 (PRS) 与哮喘 (asthma-PRS) 和 ADHD 的多基因风险评分 (PRS) 之间的关联。

方法：

我们分析了 3,574 人在出生、2、22 和 30 岁时收集的数据。

结果：

ADHD 受试者患哮喘的风险增加（OR 1.92，95% CI 1.01–3.66）。这种关联对女性来说更强。我们的结果显示没有证据表明 ADHD-PRSs 与哮喘或哮喘-PRSs 与 ADHD 之间存在关联。然而，一项探索性分析表明，成人 ADHD 可能与哮喘有遗传相关性。

结论：

我们的结果不支持两种情况之间的共同遗传背景。应根据重要的局限性来看待研究结果，特别是样本量和自我报告的哮喘诊断。需要对更大的数据集进行研究，以更好地探索成人 ADHD 和哮喘之间的遗传重叠。