Abstract

In this work, water-soluble polymer composites containing two antimicrobial components, silver nanoparticles and phenol ligands, are obtained. The maleic-acid groups of the used matrix, a copolymer of maleic acid with ethylene, contributed to the production of noncovalent polymer conjugates of p-aminophenol. In addition, they were easily transformed thermally into reactive residues of maleic anhydride, which allowed the synthesis of covalent polymer complexes of p-aminophenol. Silver nanoparticles were obtained via a reduction of the corresponding metal salt with NaBH₄ in the presence of phenol-polymer conjugates. The resulting colloidal solutions of preparations were active against a number of opportunistic microorganisms. The minimum inhibitory concentrations were 32 and 64 μg/mL for complex drugs against Escherichia coli, 8 and 16 μg/mL against Pseudomonas aeruginosa, and 4 and 8 μg/mL against Candida albicans for nanosilver-containing noncovalent and covalent polymer complexes of p-aminophenol, respectively. A pronounced synergistic effect of antibacterial components in the used conjugates is revealed in relation to the specified strains of microorganisms; the fractional inhibitory concentration indexes for the obtained composites were less than 0.5.

中文翻译：

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基于含银纳米颗粒和酚醛残留物的马来酸共聚物制剂的抗菌性能研究

摘要

在这项工作中，获得了含有两种抗菌成分、银纳米颗粒和苯酚配体的水溶性聚合物复合材料。所用基质（马来酸与乙烯的共聚物）的马来酸基团有助于生成对氨基苯酚的非共价聚合物共轭物。此外，它们很容易通过热转化为马来酸酐的活性残基，从而可以合成对氨基苯酚的共价聚合物复合物。在酚-聚合物缀合物存在下，通过用NaBH ₄还原相应的金属盐获得银纳米颗粒。所得制剂的胶体溶液对多种机会性微生物具有活性。复合药物的最低抑菌浓度分别为 32 和 64 μg/mL大肠杆菌，图8和16微克/毫升抗铜绿假单胞菌，和4和8μg/ mL的抗白色念珠菌对于含有纳米银的非共价和的共价聚合物络合物p分别氨基苯酚。所用偶联物中抗菌成分的显着协同作用与特定的微生物菌株有关；所得复合材料的抑菌浓度指数均小于0.5。