There are limited evidences clarifying the impact of metabolic syndrome (MS) and its components on head and neck cancer (HNC) incidence risk. We explored the correlation between MS, MS components, and the combined effects of MS and C-reactive protein (CRP) and HNC risk. This is a prospective analysis of 474,929 participants from the UK Biobank cohort. Cox proportional hazard regression was utilized to assess the hazard ratio (HR) and 95% confidence interval (CI) and to explore the non-linear correlation between an individual MS component and HNC risk. Individuals with MS (HR, 1.05; 95%CI, 0.90–1.22) had no higher HNC risk than those without MS. More MS components showed no higher HNC risk. Nevertheless, hyperglycemia (HR, 1.22; 95%CI, 1.02–1.45) was independently correlated with elevated HNC risk. In a non-linear manner, waist circumference and high-density lipoprotein cholesterol (HDL-C) showed a U-shaped association with HNC risk. Further, piecewise linear model analysis indicated that higher male waist circumference, female waist circumference (≥93.16 cm), blood glucose (≥4.70 mmol/L) and male HDL-C (≥1.26mmo/L), and lower male HDL-C (<1.26mmo/L) were correlated with higher HNC risk. Increased CRP (≥1.00mg/dL) elevated HNC risk and individuals with MS and CRP≥1.00mg/dL had the highest HNC risk (HR, 1.29; 95%CI, 1.05–1.58). But no joint effect between MS and CRP was detected (p-interaction=0.501). MS are not correlated with elevated HNC risk. High waist circumference and blood glucose are independent risk factor of HNC incidence. Controlling HDL-C in an appropriate range can get the lowest risk of male HNC. No joint effect of MS and CRP exists in HNC tumorigenesis.

中文翻译：

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代谢综合征对头颈癌发病风险的影响：基于人群的前瞻性队列研究

澄清代谢综合征 (MS) 及其组成部分对头颈癌 (HNC) 发病风险影响的证据有限。我们探讨了 MS、MS 组成部分以及 MS 和 C 反应蛋白 (CRP) 的综合影响与 HNC 风险之间的相关性。这是对英国生物银行队列中 474,929 名参与者的前瞻性分析。Cox 比例风险回归用于评估风险比 (HR) 和 95% 置信区间 (CI)，并探索单个 MS 成分与 HNC 风险之间的非线性相关性。患有 MS 的个体（HR，1.05；95%CI，0.90-1.22）的 HNC 风险并不比没有 MS 的个体更高。MS 成分越多，HNC 风险并不越高。然而，高血糖（HR，1.22；95%CI，1.02-1.45）与 HNC 风险升高独立相关。腰围和高密度脂蛋白胆固醇 (HDL-C) 与 HNC 风险呈 U 形关联，呈非线性关系。此外，分段线性模型分析显示，男性腰围较高，女性腰围（≥93.16 cm）、血糖（≥4.70 mmol/L）和男性HDL-C（≥1.26mmo/L）较高，男性HDL-C较低(<1.26mmo/L) 与较高的 HNC 风险相关。CRP 升高（≥1.00mg/dL）会增加 HNC 风险，患有 MS 且 CRP≥1.00mg/dL 的个体 HNC 风险最高（HR，1.29；95%CI，1.05-1.58）。但未检测到 MS 和 CRP 之间的联合效应（p 交互作用 = 0.501）。MS 与 HNC 风险升高无关。高腰围和血糖是HNC发病的独立危险因素。将HDL-C控制在适当的范围内可以使男性HNC的风险最低。MS和CRP在HNC肿瘤发生中不存在联合作用。