Double delay alternating with nutation for tailored excitation facilitates banding-free isotropic high-resolution intracranial vessel wall imaging,NMR in Biomedicine

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Double delay alternating with nutation for tailored excitation facilitates banding-free isotropic high-resolution intracranial vessel wall imaging
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-06-02 , DOI: 10.1002/nbm.4567
Bram F Coolen ₁ , Jasper Schoormans ₁ , Guillaume Gilbert ₂ , Ernst S Kooreman _{1,

3} , Naomi de Winter ₁ , Olivia Viessmann ₄ , Jaco J M Zwanenburg ₅ , Charles B L M Majoie ₆ , Gustav J Strijkers ₁ , Aart J Nederveen ₆ , Jeroen C W Siero _{5,

7}

Affiliation

The purpose of this study was to evaluate the use of a double delay alternating with nutation for tailored excitation (D-DANTE)-prepared sequence for banding-free isotropic high-resolution intracranial vessel wall imaging (IC-VWI) and to compare its performance with regular DANTE in terms of signal-to-noise ratio (SNR) as well as cerebrospinal fluid (CSF) and blood suppression efficiency. To this end, a D-DANTE–prepared 3D turbo spin echo sequence was implemented by interleaving two separate DANTE pulse trains with different RF phase-cycling schemes, but keeping all other DANTE parameters unchanged, including the total number of pulses and total preparation time. This achieved a reduction of the banding distance compared with regular DANTE enabling banding-free imaging up to higher resolutions. Bloch simulations assuming static vessel wall and flowing CSF spins were performed to compare DANTE and D-DANTE in terms of SNR and vessel wall/CSF contrast. Similar image quality measures were assessed from measurements on 13 healthy middle-aged volunteers. Both simulation and in vivo results showed that D-DANTE had only slightly lower vessel wall/CSF and vessel wall/blood contrast-to-noise ratio values compared with regular DANTE, which originated from a 10%–15% reduction in vessel wall SNR but not from reduced CSF or blood suppression efficiency. As anticipated, IC-VWI acquisitions showed that D-DANTE can successfully remove banding artifacts compared with regular DANTE with equal scan time or DANTE preparation length. Moreover, application was demonstrated in a patient with an intracranial aneurysm, indicating improved robustness to slow flow artifacts compared with clinically available 3D turbo spin echo scans. In conclusion, D-DANTE provides banding artifact-free IC-VWI up to higher isotropic resolutions compared with regular DANTE. This allows for a more flexible choice of DANTE preparation parameters in high-resolution IC-VWI protocols.

中文翻译：

用于定制激发的双延迟与章动交替有助于无条带各向同性高分辨率颅内血管壁成像

本研究的目的是评估使用双延迟与章动交替进行定制激发 (D-DANTE) 制备的无条带各向同性高分辨率颅内血管壁成像 (IC-VWI) 序列并比较其性能在信噪比 (SNR) 以及脑脊液 (CSF) 和血液抑制效率方面与常规 DANTE 相比。为此，D-DANTE 制备的 3D turbo 自旋回波序列通过使用不同的 RF 相位循环方案交织两个单独的 DANTE 脉冲序列来实现，但保持所有其他 DANTE 参数不变，包括脉冲总数和总准备时间. 与常规 DANTE 相比，这实现了条带距离的减少，从而实现了更高分辨率的无条带成像。进行假设静态血管壁和流动 CSF 自旋的 Bloch 模拟，以比较 DANTE 和 D-DANTE 在 SNR 和血管壁/CSF 对比度方面。从对 13 名健康中年志愿者的测量中评估了类似的图像质量测量。模拟和体内结果均表明，与常规 DANTE 相比，D-DANTE 的血管壁/CSF 和血管壁/血液对比噪声比值仅略低，这源于血管壁 SNR 降低了 10%–15%但不是因为脑脊液或血液抑制效率降低。正如预期的那样，IC-VWI 采集表明，与具有相同扫描时间或 DANTE 准备长度的常规 DANTE 相比，D-DANTE 可以成功去除条带伪影。此外，该应用在颅内动脉瘤患者中得到证实，表明与临床可用的 3D 涡轮自旋回波扫描相比，对慢流伪影的鲁棒性有所提高。总之，与常规 DANTE 相比，D-DANTE 提供了无条带伪影的 IC-VWI，具有更高的各向同性分辨率。这允许在高分辨率 IC-VWI 协议中更灵活地选择 DANTE 制备参数。

更新日期：2021-08-11

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