The present review asks whether magnetic resonance imaging (MRI) studies are able to define neural correlates of episodic memory within the hippocampus in Parkinson's disease (PD). Systematic searches were performed in PubMed, Web of Science, Medline, CINAHL, and EMBASE using search terms related to structural and functional MRI (fMRI), the hippocampus, episodic memory, and PD. Risk of bias was assessed for each study using the Newtown–Ottawa Scale. Thirty-nine studies met inclusion criteria; eight fMRI, seven diffusion MRI (dMRI), and 24 structural MRI (14 exploring whole hippocampus and 10 exploring hippocampal subfields). Critical analysis of the literature revealed mixed evidence from functional and dMRI, but stronger evidence from sMRI of the hippocampus as a biomarker for episodic memory impairment in PD. Hippocampal subfield studies most often implicated CA1, CA3/4, and subiculum volume in episodic memory and cognitive decline in PD. Despite differences in imaging methodology, study design, and sample characteristics, MRI studies have helped elucidate an important neural correlate of episodic memory impairment in PD with both clinical and theoretical implications. Natural progression of this work encourages future research on hippocampal subfield function as a potential biomarker of, or therapeutic target for, episodic memory dysfunction in PD.

中文翻译：

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帕金森病情景记忆的海马相关性：磁共振成像研究的系统评价

本综述询问磁共振成像 (MRI) 研究是否能够确定帕金森病 (PD) 海马内情景记忆的神经相关性。在 PubMed、Web of Science、Medline、CINAHL 和 EMBASE 中使用与结构和功能 MRI (fMRI)、海马、情景记忆和 PD 相关的搜索词进行系统搜索。使用 Newtown-Ottawa 量表评估每项研究的偏倚风险。39 项研究符合纳入标准；8 个 fMRI、7 个扩散 MRI (dMRI) 和 24 个结构 MRI（14 个探索整个海马区和 10 个探索海马亚区）。对文献的批判性分析揭示了来自功能性和 dMRI 的混合证据，但来自海马 sMRI 作为 PD 情景记忆障碍的生物标志物的更有力的证据。海马亚区研究最常将 CA1、CA3/4 和下托体积与 PD 的情景记忆和认知下降有关。尽管在成像方法、研究设计和样本特征方面存在差异，但 MRI 研究有助于阐明 PD 中情景记忆障碍的重要神经相关性，具有临床和理论意义。这项工作的自然进展鼓励了未来将海马亚区功能作为 PD 情景记忆功能障碍的潜在生物标志物或治疗靶点的研究。MRI 研究有助于阐明 PD 中情景记忆障碍的重要神经相关性，具有临床和理论意义。这项工作的自然进展鼓励了未来将海马亚区功能作为 PD 情景记忆功能障碍的潜在生物标志物或治疗靶点的研究。MRI 研究有助于阐明 PD 中情景记忆障碍的重要神经相关性，具有临床和理论意义。这项工作的自然进展鼓励了未来将海马亚区功能作为 PD 情景记忆功能障碍的潜在生物标志物或治疗靶点的研究。