The vascular endothelium, which plays an essential role in maintaining the normal shape and function of blood vessels, is a natural barrier between the circulating blood and the vascular wall tissue. The endothelial damage can cause vascular lesions, such as atherosclerosis and restenosis. After the vascular intima injury, the body starts the endothelial repair (re-endothelialization) to inhibit the neointimal hyperplasia. Endothelial progenitor cell is the precursor of endothelial cells and plays an important role in the vascular re-endothelialization. However, re-endothelialization is inevitably affected in vivo and in vitro by factors, which can be divided into two types, namely, promotion and inhibition, and act on different links of the vascular re-endothelialization. This article reviews these factors and related mechanisms.

中文翻译：

---

影响内皮祖细胞再内皮化的因素

血管内皮在维持血管的正常形状和功能方面起着至关重要的作用，是循环血液与血管壁组织之间的天然屏障。内皮损伤可引起血管病变，如动脉粥样硬化和再狭窄。血管内膜损伤后，机体开始内皮修复（再内皮化）以抑制新生内膜增生。内皮祖细胞是内皮细胞的前体，在血管再内皮化中起重要作用。然而，再内皮化不可避免地受到体内和体外的影响按因素可分为促进和抑制两类，作用于血管再内皮化的不同环节。本文综述了这些因素和相关机制。