Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such transformative tool in behavioral neuroscience research, chemogenetics (or Designer Receptors Exclusively Activated by Designer Drugs, DREADDS). As transformative technologies such as DREADDs are introduced, applied, and refined, their utility in addressing complex questions about behavior and cognition becomes clear and exciting. In the behavioral neuroscience field, remarkable new findings now regularly appear as a result of the ability to monitor and intervene in neural processes with high anatomical precision as animals behave in complex task environments. As these new tools are applied to behavioral questions, individualized procedures for their use find their way into diverse labs. Thus, "tips of the trade" become important for wide dissemination not only for laboratories that are using the tools but also for those who are interested in incorporating them into their own work. Our aim is to provide an up-to-date perspective on how the DREADD technique is being used for research on learning and memory, decision making, and goal-directed behavior, as well as to provide suggestions and considerations for current and future users based on our collective experience. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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Dreadds：在行为神经科学中的使用和应用。


过去十年的技术进步正在改变行为神经科学研究的面貌。在这里，我们回顾了最近在行为神经科学研究、化学遗传学（或由设计药物专门激活的设计受体，DREADDS）中使用此类变革性工具的工作。随着 DREADD 等变革性技术的引入、应用和完善，它们在解决有关行为和认知的复杂问题方面的效用变得清晰且令人兴奋。在行为神经科学领域，随着动物在复杂任务环境中的行为，能够以高解剖精度监测和干预神经过程，因此现在经常出现引人注目的新发现。随着这些新工具应用于行为问题，其使用的个性化程序进入了不同的实验室。因此，“行业技巧”对于广泛传播变得很重要，不仅对于使用这些工具的实验室，而且对于那些有兴趣将其纳入自己工作的人来说。我们的目标是提供有关 DREADD 技术如何用于学习和记忆、决策和目标导向行为研究的最新视角，并基于以下方面为当前和未来的用户提供建议和考虑因素：根据我们的集体经验。 （PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。