Background:

The study aims at identifying features predictive of early onset of dementia in Parkinson’s disease (PD).

Methods:

103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.

Results:

By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = −.621, p < 0.001) and insomnia (r = −.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).

Conclusion:

Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.

中文翻译：

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临床标志物可识别有早期帕金森病痴呆风险的患者：一项前瞻性研究

 背景：

该研究旨在确定帕金森病（PD）痴呆早期发作的预测特征。

 方法：

103 名非痴呆 PD 患者在基线时接受了不同程度的评估，89 名患者在 3 年随访时接受了评估。

 结果：

到研究结束时，43.8% 的患者出现痴呆症。痴呆症的发生与基线简易精神状态检查评分（皮尔逊系数 r = .404，p = 0.013）、自主神经功能障碍（r = −.621，p < 0.001）和失眠（r = − .526，p = 0.001）。二元逻辑回归分析显示，痴呆症的发生与自主神经功能障碍（95% CI 2.60 至 52.83，p < 0.001）和失眠（95% CI 0.60 至 0.95，p = 0.017）密切相关。

 结论：

有自主神经功能障碍和失眠症状的患者患痴呆症的风险较高，应密切监测认知症状。