Abstract

It is well known that poly(2-methoxyethyl acrylate) (PMEA) has good blood compatibility and its performance is attributed to its water structure. Recently, we applied solution nuclear magnetic resonance spectroscopy (solution-NMR) for analyzing the water structure in PMEA at ambient temperature and concluded that this method is useful because of the clear observation of the resonance peaks at low and high magnetic field (downfield and upfield, respectively) areas indicating the existence of more than two types of water. The present study was performed to compare the water structure of poly(tetrahydrofurfuryl acrylate) (PTHFA) and poly(2-hydroxyethyl methacrylate) (PHEMA) using solution ²H-NMR and deuterium oxide as water at the temperature range 15–45 °C. It was found that PTHFA has a different water structure from that of PHEMA. Water in PTHFA clearly showed two resonance peaks at downfield and upfield areas, with different spin-lattice relaxation times, T₁^2H (high and low values, respectively). These observations are similar to those of PMEA. In contrast, PHEMA showed only one broad resonance peak (at downfield) with a low T₁^2H value. Based on these observations, this study discusses the effect of water structures on the blood compatibility of these polymers.

摘要

众所周知，聚（2-甲氧基丙烯酸乙酯）（PMEA）具有良好的血液相容性，其性能归功于其水结构。最近，我们应用溶液核磁共振波谱 (solution-NMR) 来分析环境温度下 PMEA 中的水结构，并得出结论认为该方法是有用的，因为在低磁场和高磁场（下场和上场）下可以清楚地观察共振峰，分别）表明存在两种以上水的区域。本研究使用溶液²比较聚（丙烯酸四氢糠酯）（PTHFA）和聚（甲基丙烯酸 2-羟乙酯）（PHEMA）的水结构H-NMR 和氧化氘在 15–45 °C 的温度范围内作为水。发现 PTHFA 具有与 PHEMA 不同的水结构。PTHFA 中的水在低场和高场区域清楚地显示出两个共振峰，具有不同的自旋晶格弛豫时间，T ₁ ^2H（分别为高值和低值）。这些观察结果类似于 PMEA 的观察结果。相比之下，PHEMA 仅显示一个宽共振峰（在低场），具有低 T ₁ ^2H值。基于这些观察，本研究讨论了水结构对这些聚合物血液相容性的影响。