The outbreak of mysterious pneumonia at the end of 2019 is associated with widespread research interest worldwide. The coronavirus disease-19 (COVID-19) targets multiple organs through inflammatory, immune, and redox mechanisms, and no effective drug for its prophylaxis or treatment has been identified until now. The use of dietary bioactive compounds, such as phenolic compounds (PC), has emerged as a putative nutritional or therapeutic adjunct approach for COVID-19. In the present study, scientific data on the mechanisms underlying the bioactivity of PC and their usefulness in COVID-19 mitigation are reviewed. In addition, antioxidant, antiviral, anti-inflammatory, and immunomodulatory effects of dietary PC are studied. Moreover, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota. Lastly, safety issues and possible drug interactions of PC and their implications in COVID-19 therapeutics are discussed.

2019 年底爆发的神秘肺炎与全球广泛的研究兴趣有关。冠状病毒病 19 (COVID-19) 通过炎症、免疫和氧化还原机制靶向多个器官，目前尚未发现有效的预防或治疗药物。使用膳食生物活性化合物，如酚类化合物 (PC)，已成为 COVID-19 的一种推定的营养或治疗辅助方法。在本研究中，审查了有关 PC 生物活性机制的科学数据及其在缓解 COVID-19 方面的作用。此外，还研究了膳食 PC 的抗氧化、抗病毒、抗炎和免疫调节作用。而且，通过解决肠道微生物群对 PC 的生物利用度和生物转化，提出了消化对膳食 PC 对抗 COVID-19 的假定益处的影响。最后，讨论了 PC 的安全问题和可能的药物相互作用及其在 COVID-19 治疗中的意义。