Objective. Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. The aim of this study was to investigate the prevalence of anal canal HR HPV infection among men who have sex with men (MSM) with and without HIV infection in Moscow (Russia). We evaluated associations of some HIV coinfections (HSV and CMV) and HPV distribution among MSM with and without HIV infection. Methods. Two groups of HIV-positive (n = 60) and HIV-negative (n = 60) MSM were evaluated in the study. Fourteen high-risk (HR) HPV types, HSV1/2, and CMV were investigated in men anal swabs. Results. HR HPVs were found with nearly the same frequency of 66.7% in both groups: HIV-positive and HIV-negative MSM. HIV-positive status was statistically associated with the presence of several (more than two) HPV types (). The most prevalent HR HPV genotypes were HPV18, HPV16, HPV56, and HPV33 for HIV-positive MSM and HPV56, HPV51, HPV66, and HPV16 for HIV-negatives. We found a statistically significant association of five HR HPV types with HIV status of MSM: HPV16 (), HPV18 (), HPV58 (), HPV33 (), and HPV39 (). The frequency of HSV1 (1.7%) and HSV2 (10%) infections and CMV (3.3%) infection was evaluated in the group of HIV-positive MSM. The frequency of HSV1 (5%) and HSV2 (6.7%) infections and CMV (0%) infection was evaluated, as well, in the group of HIV-negative MSM. Conclusion. Multiple HPV genotypes were detected significantly more often than single HPV genotype in the group of HIV-positive MSM. According to our data, 25% of HIV-positive MSM have HPV39; this is the only one of the five types of HR HPV (16, 18, 58, 33, and 39) associated with this group of MSM that has not yet been included in the HPV vaccines available on the market.

中文翻译：

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俄罗斯 HIV 阳性和 HIV 阴性 MSM 中 HPV 基因型高致癌风险的患病率

目标。男男性行为者 (MSM) 因高危人乳头瘤病毒 (HR HPV) 感染导致终生肛门癌的风险很高。本研究的目的是调查莫斯科（俄罗斯）感染和未感染 HIV 的男男性行为者 (MSM) 肛管 HR HPV 感染的流行情况。我们评估了一些 HIV 合并感染（HSV 和 CMV）与 HPV 分布在有和没有 HIV 感染的 MSM 之间的关联。方法。 在研究中评估了两组 HIV 阳性 ( n  = 60) 和 HIV 阴性 ( n = 60) MSM。在男性肛门拭子中研究了 14 种高危 (HR) HPV 类型、HSV1/2 和 CMV。结果. 在两组中发现 HR HPV 的频率几乎相同，均为 66.7%：HIV 阳性和 HIV 阴性 MSM。HIV 阳性状态与多种（超过两种）HPV 类型的存在具有统计学相关性（）。最普遍的 HR HPV 基因型是 HIV 阳性 MSM 的 HPV18、HPV16、HPV56 和 HPV33，以及 HIV 阴性的 HPV56、HPV51、HPV66 和 HPV16。我们发现五种 HR HPV 类型与 MSM 的 HIV 状态存在统计学显着关联：HPV16（), HPV18 (), HPV58 (), HPV33 ()和 HPV39 (）。在 HIV 阳性 MSM 组中评估了 HSV1 (1.7%) 和 HSV2 (10%) 感染和 CMV (3.3%) 感染的频率。在 HIV 阴性 MSM 组中还评估了 HSV1 (5%) 和 HSV2 (6.7%) 感染和 CMV (0%) 感染的频率。结论。在 HIV 阳性 MSM 组中，检测到多种 HPV 基因型的频率明显高于单一 HPV 基因型。根据我们的数据，25% 的 HIV 阳性 MSM 有 HPV39；这是与这组 MSM 相关的五种 HR HPV（16、18、58、33 和 39）中唯一一种尚未包含在市场上可用的 HPV 疫苗中。