Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus,Clinical & Translational Immunology

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Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-06-01 , DOI: 10.1002/cti2.1293
Kaili Liang ₁ , Jing He ₂ , Yunbo Wei ₃ , Qunxiong Zeng ₁ , Dongcheng Gong ₁ , Jiahuan Qin ₁ , Huihua Ding _{4,

5} , Zhian Chen ₆ , Ping Zhou ₄ , Peng Niu ₄ , Qian Chen ₇ , Chenguang Ding ₈ , Liangjing Lu ₅ , Xiao-Xiang Chen ₅ , Zhanguo Li ₂ , Nan Shen _{1,

4,

5,

9} , Di Yu _{1,

3,

6} , Jun Deng _{1,

9}

Affiliation

China-Australia Centre for Personalized Immunology Renji Hospital Shanghai Jiao Tong University School of Medicine (SJTUSM) Shanghai China.
Department of Rheumatology and Immunology Peking University People's Hospital Beijing China.
Laboratory of Immunology for Environment and Health School of Pharmaceutical Sciences Qilu University of Technology (Shandong Academy of Sciences) Jinan China.
Shanghai Institute of Rheumatology Renji Hospital Shanghai Jiao Tong University School of Medicine (SJTUSM) Shanghai China.
Department of Rheumatology Renji Hospital Shanghai Jiao Tong University School of Medicine (SJTUSM) Shanghai China.
Faculty of Medicine The University of Queensland Diamantina Institute The University of Queensland Brisbane QLD Australia.
Department of Ophthalmology Shanghai General Hospital (Shanghai First People's Hospital) School of Medicine Shanghai Jiao Tong University Shanghai China.
Department of Kidney Transplantation Nephropathy Hospital the First Affiliated Hospital of Xi'an Jiaotong University Xi'an China.
State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine (SJTUSM) Shanghai China.

Low-dose interleukin-2 (IL-2) has shown promising clinical benefits in the treatment of systemic lupus erythematosus (SLE), but how this therapy alleviates pathogenic humoral immunity remains not well understood. The dilemma is that IL-2 can suppress both follicular helper and regulatory T (Tfh and Tfr) cells, which counteract each other in regulating autoantibody production.

中文翻译：

持续的低剂量白细胞介素 2 疗法通过提高狼疮的 Tfr/Tfh 比率来减轻病原性体液免疫

低剂量白细胞介素 2 (IL-2) 在治疗系统性红斑狼疮 (SLE) 中显示出有希望的临床益处，但这种疗法如何减轻病原性体液免疫仍不清楚。困境在于 IL-2 可以抑制滤泡辅助细胞和调节性 T（Tfh 和 Tfr）细胞，它们在调节自身抗体产生时相互抵消。

更新日期：2021-06-02

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