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New Sugar Based γ-Amino Silyl Ether Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins
Heterocycles ( IF 0.8 ) Pub Date : 2021-06-01 , DOI: 10.3987/com-21-s(r)2
Hiroto Nakano , Divakar Ganesan , Perumalsamy Parasuraman , Zubeda Begum , Chigusa Seki , Yuko Okuyama , Eunsang Kwon , Koji Uwai , Michio Tokiwa , Suguru Tokiwa , Mitsuhiro Takeshita , Rajkumar Thiyagarajan

New sugar based γ-amino silyl ether organocatalysts were synthesized and their catalytic ability was examined in asymmetric Michael addition of β-keto esters with nitroolefins affording chiral Michael adducts with quaternary carbon stereocenter in good to excellent chemical yields, diastereoselectivities and moderate enantioselectivities (up to 97%, up to dr. 85:15, up to 56% ee).

中文翻译:

新型糖基γ-氨基甲硅烷基醚有机催化剂用于β-酮酯与硝基烯烃的不对称迈克尔加成

合成了新的基于糖的 γ-氨基甲硅烷基醚有机催化剂,并在 β-酮酯与硝基烯烃的不对称迈克尔加成中检测了它们的催化能力,从而得到具有季碳立体中心的手性迈克尔加合物,具有良好至优异的化学收率、非对映选择性和中等对映选择性(高达97%,高达85:15博士,高达 56% ee )。
更新日期:2021-06-01
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