Abstract

Background

Microwaves (MWs) deliver relatively high temperatures into biological tissue and cover a large ablation zone. This study aims to evaluate the efficacy and effectiveness of water-cooled double-needle MW ablation arrays in assisting the hepatic transection of an in vivo pig model.

Methods

Our research program comprised computer modeling, tissue-mimicking phantom experiments, and in vivo pig liver experiments. Computer modeling was based on the finite element method (FEM) to evaluate ablation temperature distributions. In tissue-mimicking phantom and in vivo pig liver ablation experiments, the performances of the water-cooled MW ablation array and conventional clamp crushing liver resection were compared.

Results

FEM showed that the maximum lateral ablation diameter at 100 W output and a duration of 60 s was 3 cm (assessed at 50 °C isotherm). In the phantom, the maximum transverse ablation diameter of the double-needle MW ablation increased rapidly to 3 cm in 60 s at 50 W. The blood loss and blood loss per transection area in Group A were significantly lower than those in Group B (18 (7–26) ml vs. 34 (19–57) ml, and 2.4 (2–3.1) ml/cm² vs. 6.9 (3.2–8.3) ml/cm², respectively) (p < 0.05). The transection speed in Group A (2.6(1.9–3.8) cm²/min) was significantly faster than that in Group B (1.7(1.1–2.2) cm²/min) (p < 0.05).

Conclusion

In this experimental model, the new water-cooled MW array-assisted liver resection (LR) has the potential advantage of less blood loss and rapid removal than the conventional LR.

中文翻译：

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水冷微波消融阵列用于肝脏无血快速横切

摘要

背景

微波 (MW) 将相对较高的温度传递到生物组织中并覆盖大的消融区。本研究旨在评估水冷双针 MW 消融阵列在协助体内猪模型肝横断方面的功效和有效性。

方法

我们的研究计划包括计算机建模、组织模拟体模实验和体内猪肝实验。计算机建模基于有限元方法 (FEM) 来评估烧蚀温度分布。在组织模拟体模和活体猪肝消融实验中，比较了水冷微波消融阵列和常规钳压碎肝切除术的性能。

结果

FEM 显示在 100 W 输出和 60 s 持续时间下的最大横向消融直径为 3 cm（在 50 °C 等温线评估）。在体模中，双针微波消融的最大横向消融直径在 50 W 60 s 内迅速增加至 3 cm。A 组的失血量和每横断面失血量显着低于 B 组（18 (7–26) ml 与 34 (19–57) ml 和 2.4 (2–3.1) ml/cm ^{2 分别}与 6.9 (3.2–8.3) ml/cm ² ) ( p  < 0.05)。A组的横断速度（2.6（1.9-3.8）cm ² /min）明显快于B组（1.7（1.1-2.2）cm ² /min）（p  < 0.05）。

结论

在该实验模型中，新型水冷微波阵列辅助肝切除术 (LR) 与传统 LR 相比，具有失血少、切除速度快的潜在优势。