Cycloisomerization of π-Coupled Heteroatom Nucleophiles by Gold Catalysis: En Route to Regiochemically Defined Heterocycles,The Chemical Record

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Cycloisomerization of π-Coupled Heteroatom Nucleophiles by Gold Catalysis: En Route to Regiochemically Defined Heterocycles
The Chemical Record ( IF 7.0 ) Pub Date : 2021-06-01 , DOI: 10.1002/tcr.202100105
Chandrasekar Praveen ₁

Affiliation

Since the dawn of millennium, catalytic gold chemistry is at the forefront to set off diverse organic reactions via unique activation of π-bonded molecules. Within this purview, cycloisomerization of heteroatom nucleophiles linked to a π-system is one of the well recognized chemistry for the construction of numerous heterocyclic cores. Though the rudimentary aspects of this transformation are reviewed by several groups in different timeline, a holistic view on regiochemistry of such reactions went largely overlooked. Hence, this account emphasizes the gold catalyzed regioselective cycloisomerization of structurally distinctive π-connected hetero-nucleophiles leading to different heterocycles documented in the last two decades. From an application perspective, this account also highlights those methodologies which find a role in the total synthesis of natural products. Wherever appropriate, mechanistic details and contributing factors for selectivity are also discussed.

中文翻译：

金催化下 π 偶联杂原子亲核试剂的环异构化：通往区域化学定义的杂环

自千禧年以来，催化金化学处于最前沿，通过以下方式引发各种有机反应π键分子的独特激活。在此范围内，连接到 π 系统的杂原子亲核试剂的环异构化是构建众多杂环核的公认化学方法之一。尽管这种转变的基本方面由不同时间线的几个小组审查，但对此类反应的区域化学的整体看法在很大程度上被忽视了。因此，这个描述强调了金催化的结构独特的 π 连接杂亲核试剂的区域选择性环异构化，导致了过去二十年中记录的不同杂环。从应用的角度来看，这篇文章还强调了那些在天然产物全合成中发挥作用的方法。在适当的地方，

更新日期：2021-07-12

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