当前位置: X-MOL 学术Eur. J. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
HMGB1 promotes CXCL12-dependent egress of murine B cells from Peyer's patches in homeostasis
European Journal of Immunology ( IF 4.5 ) Pub Date : 2021-06-01 , DOI: 10.1002/eji.202049120
Lorenzo Spagnuolo 1, 2, 3, 4 , Viola Puddinu 2, 3, 4 , Noémie Boss 1 , Thibaud Spinetti 1, 5 , Anne Oberson 1 , Jerome Widmer 1 , Inès Mottas 1, 2, 3, 4 , Christian Hotz 1 , Marco E Bianchi 6 , Mariagrazia Uguccioni 7, 8 , Carole Bourquin 1, 2, 3, 4
Affiliation  

High mobility group box-1 protein (HMGB1) is an alarmin that, once released, promotes inflammatory responses, alone and as a complex with the chemokine CXCL12. Here, we report that the HMGB1–CXCL12 complex plays an essential role also in homeostasis by controlling the migration of B lymphocytes. We show that extracellular HMGB1 is critical for the CXCL12-dependent egress of B cells from the Peyer's patches (PP). This promigratory function of the complex was restricted to the PPs, since HMGB1 was not required for B-cell migratory processes in other locations. Accordingly, we detected higher constitutive levels of the HMGB1–CXCL12 complex in PPs than in other lymphoid organs. HMGB1–CXCL12 in vivo inhibition was associated with a reduced basal IgA production in the gut. Collectively, our results demonstrate a role for the HMGB1–CXCL12 complex in orchestrating B-cell trafficking in homeostasis, and provide a novel target to control lymphocyte migration in mucosal immunity.

中文翻译:

HMGB1 促进 CXCL12 依赖的小鼠 B 细胞从 Peyer 斑块在体内平衡中流出

高迁移率族框 1 蛋白 (HMGB1) 是一种警报,一旦释放,就会促进炎症反应,单独或与趋化因子 CXCL12 形成复合物。在这里,我们报告 HMGB1-CXCL12 复合物通过控制 B 淋巴细胞的迁移在体内平衡中也起着重要作用。我们表明,细胞外 HMGB1 对于 B 细胞从 Peyer 斑块 (PP) 的 CXCL12 依赖性出口至关重要。复合物的这种迁移功能仅限于 PP,因为其他位置的 B 细胞迁移过程不需要 HMGB1。因此,我们检测到 PPs 中 HMGB1-CXCL12 复合物的组成水平高于其他淋巴器官。HMGB1-CXCL12 体内抑制与肠道中基础 IgA 产生减少有关。总的来说,
更新日期:2021-08-05
down
wechat
bug