In this article, we propose a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC). These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC. We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images. The microenvironment of PCPC surface is essential for promoting BMSCs’ proliferation and differentiation. These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats. Moreover, PCPC/BBR had significantly increased the expression levels of ALP, osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.

中文翻译：

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黄连功能化多孔磷酸钙支架修复骨质疏松大鼠颅骨缺损

在本文中，我们提出了一种使用小檗碱 (BBR) 改性多孔磷酸钙陶瓷（命名为 PCPC）的简单方案。这些 BBR 分子调节 PCPC 上羟基磷灰石纳米棒的结晶。我们通过SEM图像发现这些纳米棒和吸附的BBR改变了PCPC的界面微环境。PCPC表面的微环境对于促进BMSCs的增殖和分化至关重要。这些结果表明，PCPC/BBR 显着改善了骨质疏松大鼠的骨再生。此外，PCPC/BBR 显着增加了骨质疏松大鼠骨髓间充质干细胞中 ALP、骨钙素和骨形态发生蛋白 2 和 RUNX2 的表达水平。