Joint effects of antibiotics and quorum sensing inhibitors on resistance development in bacteria,Environmental Science: Processes & Impacts

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Joint effects of antibiotics and quorum sensing inhibitors on resistance development in bacteria
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2021-5-11 , DOI: 10.1039/d1em00047k
Qing Ning ₁ , Dali Wang ₁ , Jing You ₁

Affiliation

Quorum sensing inhibitors (QSIs) are promising alternatives to antibiotics. While QSIs have great application potential in a variety of fields, their joint effects with antibiotics on bacteria, especially on antibiotic resistance mutations, remain largely unexplored. Herein, we report the joint effects of four commonly used antibiotics and two QSIs on bacterial growth and resistance mutations in E. coli. It was found that QSIs presented antagonistic or additive effects with antibiotics on bacterial growth, and more importantly, QSIs exhibited an attenuating effect on antibiotic-induced resistance mutations. Further analysis demonstrated that antibiotics might enhance resistance mutations by promoting the expressions of rpoS, lexA and recA, while QSIs attenuated the mutations by promoting the expressions of mutS and uvrD. The present research provides a comprehensive understanding of the joint effects of antibiotics and QSIs on bacteria, which may benefit the risk assessment of their combined exposure.

中文翻译：

抗生素和群体感应抑制剂对细菌耐药性发展的联合作用

群体感应抑制剂（QSI）是抗生素的有前途的替代品。虽然 QSI 在各个领域具有巨大的应用潜力，但它们与抗生素对细菌的联合作用，尤其是对抗生素耐药性突变的影响，在很大程度上仍未得到探索。在这里，我们报告的四种常用的抗生素和两个QSIs对细菌的生长和耐药突变的共同作用的大肠杆菌。研究发现，QSIs 与抗生素对细菌生长具有拮抗或相加作用，更重要的是，QSIs 对抗生素诱导的耐药突变具有减弱作用。进一步的分析表明，抗生素可能通过促进rpoS、lexA和recA的表达来增强耐药突变。，而 QSI 通过促进mutS和uvrD的表达来减弱突变。目前的研究提供了对抗生素和 QSI 对细菌的联合作用的全面了解，这可能有助于对其联合暴露的风险评估。

更新日期：2021-06-01

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