Underactive bladder and impaired bladder compliance are irreversible problems associated with bladder fibrosis. Remodeling of the extracellular matrix is regarded as an important mechanism associated with bladder fibrosis. However, various risk factors and conditions contribute to the functional impairment of the bladder associated with fibrosis, and there is limited knowledge about bladder fibrosis-associated problems in the field of neurourology. Further studies are thus necessary to elucidate the underlying mechanism of bladder fibrosis and to identify effective treatment.

中文翻译：

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纤维化引起的不可逆膀胱重塑。

膀胱活动不足和膀胱顺应性受损是与膀胱纤维化相关的不可逆转的问题。细胞外基质的重塑被认为是与膀胱纤维化相关的重要机制。然而，各种风险因素和条件会导致与纤维化相关的膀胱功能障碍，并且在神经泌尿学领域对膀胱纤维化相关问题的了解有限。因此，需要进一步的研究来阐明膀胱纤维化的潜在机制并确定有效的治疗方法。