In this study, the protective effect of voluntary wheel running exercise on muscle loss and muscle weakness in gastrocnemius of old rats was investigated. The association of voluntary wheel exercise with the peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α)/fibronectin type III domain-containing protein 5 (FNDC5)/adenosine monophosphate- activated protein kinase (AMPK) signaling pathway and vascular endothelial growth factor (VEGF) expression was also evaluated.

中文翻译：

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自愿轮跑运动通过激活过氧化物酶体增殖物激活受体伽玛辅激活因子-1α/纤连蛋白 III 型结构域蛋白 5/腺苷单磷酸激活蛋白激酶信号通路来改善衰老引起的肌肉减少症。

本研究探讨了随意轮跑运动对老年大鼠腓肠肌肌肉流失和肌无力的保护作用。自愿轮运动与过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）/纤连蛋白III型结构域蛋白5（FNDC5）/磷酸腺苷激活蛋白激酶（AMPK）信号通路和血管内皮生长的关联因子（VEGF）的表达也进行了评估。