Is the Strongest Level of Medical Evidence Always Required for Guidelines Recommendations?,Liver Cancer

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Is the Strongest Level of Medical Evidence Always Required for Guidelines Recommendations?
Liver Cancer ( IF 11.6 ) Pub Date : 2021-06-01 , DOI: 10.1159/000516196
Matteo Ravaioli _{1,

2} , Fabio Piscaglia _{1,

3} , Umberto Cillo ₄ , Giovanni Brandi _{5,

6} , Maurizio Sessa ₇ , Giuliana Germinario ₂ , Rita Golfieri _{5,

8} , Alberta Cappelli ₈ , Maria C Morelli ₂ , Antonio Siniscalchi ₉ , Antonietta D'Errico _{5,

10} , Matteo Cescon _{1,

2} , Primiano Iannone ₁₁ , Franco Trevisani _{1,

12}

Affiliation

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Dipartimento di Chirurgia Generale e Trapianti, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Division of Internal Medicine, Department of Digestive Disease and Internal Medicine, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy.
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Division of Oncology, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Radiology Unit, Department of Digestive Disease and Internal Medicine, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Division of Anesthesiology, Department of Anesthesia and Intensive Care, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Pathology Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Centro Eccellenza Clinica, Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Semeiotica Medica Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.