This study assesses the effectiveness of a multicomponent Longitudinal Cognitive Training (CT) program plus physical exercise (PE) for people with Mild Cognitive Impairment (MCI). 155 people with MCI, completed a 3 years (3Y) CT+PE, whilst 133 were control. Neuropsychological assessment was performed at baseline and 3 years later, whilst CT+PE had additional annual assessments. According to the results, the 3Y CT+PE outperformed control in cognitive abilities (p < 0.002), and Activities of Daily Living (ADL) (p < 0.001), stabilized their functional performances between 1st and 2nd year, but worsened in working and verbal memory between 2nd and 3 rd year (p < 0.002). Control deteriorated in cognitive functions (p < 0.001) and ADL (p < 0.001) after 3 years, whilst 1.33% of the experimental and 13.53% of the control group progressed to dementia (p < 0.001). Longitudinal CT+PE improves cognitive performance and ADL in MCI and delay the progression to dementia.

本研究评估了多组分纵向认知训练 (CT) 计划加体育锻炼 (PE) 对轻度认知障碍 (MCI) 人群的有效性。155 名 MCI 患者完成了 3 年 (3Y) CT+PE，而 133 人为对照组。神经心理学评估在基线和 3 年后进行，而 CT+PE 有额外的年度评估。结果显示，3Y CT+PE 在认知能力 ( p < 0.002) 和日常生活活动 (ADL) ( p < 0.001) 方面的表现优于对照组，在第 1 年和第 2 年之间稳定了他们的功能表现，但在工作和第 2 年和第 3 年之间的语言记忆（p < 0.002）。认知功能 ( p < 0.001) 和 ADL (p < 0.001) 3 年后，而 1.33% 的实验组和 13.53% 的对照组进展为痴呆症 ( p < 0.001)。纵向 CT+PE 可改善 MCI 的认知能力和 ADL，并延缓痴呆的进展。