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Progress in sensorimotor neuroscience of schizophrenia spectrum disorders: Lessons learned and future directions
Progress in Neuro-Psychopharmacology and Biological Psychiatry ( IF 5.6 ) Pub Date : 2021-06-01 , DOI: 10.1016/j.pnpbp.2021.110370
Dusan Hirjak 1 , Andreas Meyer-Lindenberg 1 , Fabio Sambataro 2 , Stefan Fritze 1 , Jacqueline Kukovic 3 , Katharina M Kubera 4 , Robert C Wolf 4
Affiliation  

The number of neuroimaging studies on movement disorders, sensorimotor, and psychomotor functioning in schizophrenia spectrum disorders (SSD) has steadily increased over the last two decades. Accelerated by the addition of the “sensorimotor domain” to the Research Domain Criteria (RDoC) framework in January 2019, neuroscience research on the role of sensorimotor dysfunction in SSD has gained greater scientific and clinical relevance. To draw attention to recent rapid progress in the field, we performed a triennial systematic review (PubMed search from January 1st, 2018 through December 31st, 2020), in which we highlight recent neuroimaging findings and discuss methodological pitfalls as well as challenges for future research. The identified magnetic resonance imaging (MRI) studies suggest that sensorimotor abnormalities in SSD are related to cerebello-thalamo-cortico-cerebellar network dysfunction. Longitudinal and interventional studies highlight the translational potential of the sensorimotor domain as putative biomarkers for treatment response and as targets for non-invasive neurostimulation techniques in SSD.



中文翻译:

精神分裂症谱系障碍感觉运动神经科学的进展:经验教训和未来方向

在过去的二十年里,关于精神分裂症谱系障碍 (SSD) 中运动障碍、感觉运动和精神运动功能的神经影像学研究数量稳步增加。随着 2019 年 1 月将“感觉运动领域”添加到研究领域标准 (RDoC) 框架中,有关感觉运动功能障碍在 SSD 中作用的神经科学研究获得了更大的科学和临床相关性。为了引起对该领域近期快速进展的关注,我们进行了三年一次的系统评价(PubMed 搜索,从2018 年1 月 1日到 12 月 31日,2020),我们在其中重点介绍了最近的神经影像学发现,并讨论了方法上的缺陷以及未来研究的挑战。已确定的磁共振成像 (MRI) 研究表明,SSD 中的感觉运动异常与小脑-丘脑-皮质-小脑网络功能障碍有关。纵向和介入研究强调了感觉运动域作为治疗反应的推定生物标志物和作为 SSD 中非侵入性神经刺激技术的目标的转化潜力。

更新日期:2021-06-07
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