Plumbago zeylanica is an effective medicinal plant and a potent herb for various diseases. The leaves of P. zeylanica were subjected to crude extraction using Ethyl acetate. Chromatographic analysis of the crude extracts of P. zeylanica were studied in thin layer chromatography on a silica gel matrix. Further the extracts were purified in column chromatography and the fractions were eluted in Ethyl acetate, Chloroform solvent system. The molecules eluted in the fractions were checked in UV-spectroscopy and further characterised by GC-MS analysis. Phenol, 2,4, bis (1,1-dimethyl ethyl)-(7311) highlighted from the chromatographic studies was studied for in silico anticancer effect on matrix metalloproteins, whose dysfunction cause oral squamous cell carcinoma.

中文翻译：

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白花植物化学物质的生物化学和抗癌活性的体外和计算机模拟研究

Plumbago zeylanica是一种有效的药用植物，也是治疗各种疾病的有效药草。使用乙酸乙酯对P. zeylanica的叶子进行粗提取。在硅胶基质上的薄层色谱中研究了P. zeylanica粗提取物的色谱分析。提取物进一步在柱色谱中纯化，级分在乙酸乙酯、氯仿溶剂系统中洗脱。在紫外光谱中检查级分中洗脱的分子，并通过 GC-MS 分析进一步表征。对色谱研究中突出显示的苯酚, 2,4, 双 (1,1-二甲基乙基)-(7311) 进行了计算机模拟研究 对基质金属蛋白的抗癌作用，其功能障碍会导致口腔鳞状细胞癌。