Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/β-catenin signaling following ischemic stroke,CNS Neuroscience & Therapeutics

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Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/β-catenin signaling following ischemic stroke
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-31 , DOI: 10.1111/cns.13661
Ya-Bin Ji _{1,

2,

3} , Tian-Xi Wang ₁ , Qiang Gao _{1,

4} , Xiao-Wen Huang ₁ , Junlei Chang ₁

Affiliation

Endothelial canonical (Wnt/β-catenin) and non-canonical Wnt signalings (Wnt/PCP and Wnt/Ca²⁺) promote blood-brain barrier (BBB) development and antagonize each other. However, the effects of ischemic stroke on endothelial canonical and non-canonical Wnt signalings are unclear. Further, how non-canonical Wnt signalings are influenced by upregulation of endothelial Wnt/β-catenin signaling and subsequently affect BBB function following ischemic stroke have not been studied.

中文翻译：

非经典 Wnt 信号转导的正常化不会损害缺血性中风后上调内皮 Wnt/β-连环蛋白信号转导所赋予的血脑屏障保护

内皮经典（Wnt/β-连环蛋白）和非经典 Wnt 信号（Wnt/PCP 和 Wnt/Ca ²⁺ ）促进血脑屏障 (BBB) 发育并相互拮抗。然而，缺血性中风对内皮经典和非经典 Wnt 信号传导的影响尚不清楚。此外，尚未研究非经典 Wnt 信号传导如何受到内皮 Wnt/β-连环蛋白信号传导上调的影响，并随后影响缺血性中风后的 BBB 功能。

更新日期：2021-08-05

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