The damage to the enteric nervous system structures and the localization of total and phosphorylated α-synuclein, the main pathomorphological marker of parkinsonism, were studied by immunomorphological methods on small intestine wholemounts from rats with parkinsonism induced by systemic administration of paraquat. Reduced density of neurons in the myenteric ganglia and degenerative changes with accumulation of phosphorylated α-synuclein in sympathetic afferents to the small intestine were revealed. Phosphorylated α-synuclein was also found in non-neuronal cells located outside the ganglia. The revealed changes presumably reflect the initial stage of spreading of the pathological process during the development of Parkinson’s disease.

采用免疫形态学方法对全身给药百草枯诱发的帕金森病大鼠小肠组织进行免疫形态学研究，研究了对肠神经系统结构的损害以及总和磷酸化α-突触核蛋白的定位，这是帕金森病的主要病理形态学标志物。揭示了肌间神经节中神经元密度的降低和小肠交感传入神经中磷酸化α-突触核蛋白积累的退行性变化。在位于神经节外的非神经元细胞中也发现了磷酸化的 α-突触核蛋白。所揭示的变化可能反映了帕金森病发展过程中病理过程传播的初始阶段。