Extensive studies of the rudimental tissues taken from patients with aplasia of the uterus and vagina are aimed at elucidation of the mechanisms of the genesis of these malformations and at the search of the ways of their correction. We performed a histological examination of human uterine rudiments and immunohistochemical analysis of the expression of estrogen and progesterone receptors, VEGF, and stem/progenitor cell markers in these tissues. We found that the rudimental tissues show signs of disorganized histogenesis, but retain activity and contain cells expressing estrogen and progesterone receptors and VEGF as well as poorly differentiated precursor cells or stem cells. The presented data contribute to the in-depth studies of the mechanisms of formation of uterine rudiments and development of methods of their correction.

对取自子宫和阴道发育不全患者的原始组织进行的广泛研究旨在阐明这些畸形的发生机制并寻找纠正方法。我们对人类子宫雏形进行了组织学检查，并对这些组织中雌激素和孕激素受体、VEGF 和干/祖细胞标志物的表达进行了免疫组织化学分析。我们发现原始组织显示出组织发生紊乱的迹象，但保留了活性并含有表达雌激素和孕激素受体和 VEGF 的细胞以及分化差的前体细胞或干细胞。所提供的数据有助于深入研究子宫雏形的形成机制和纠正方法的发展。