Deep brain stimulation (DBS) is used to treat the motor symptoms of Parkinson's disease patients by stimulating the subthalamic nucleus. However, optimization of DBS is still needed since the performance of the neural electrodes is limited by the body's response to the implant. This review discusses the issues with DBS, such as placement of electrodes, foreign body response, and electrode degradation. The current solutions to these technical issues include modifications to electrode material, coatings, and geometry.

中文翻译：

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深部脑刺激：组织电极界面的挑战和当前的解决方案

深部脑刺激 (DBS) 用于通过刺激丘脑底核来治疗帕金森病患者的运动症状。然而，仍然需要优化 DBS，因为神经电极的性能受到身体对植入物的反应的限制。这篇综述讨论了 DBS 的问题，例如电极的放置、异物反应和电极退化。目前对这些技术问题的解决方案包括对电极材料、涂层和几何形状的修改。