Di-isononyl phthalate (DIP) is considered a high molecular-weight subtype of phthalates that are commonly used and could easily affect the gastrointestinal tract (GIT). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the main active components of fish oil (FO), and their anti-inflammatory potential was previously documented. The current study was designed to investigate the protective potential of fish oil against the impacts of DIP exposure on the colon of albino Wistar rats. Sixty albino Wistar rats were divided into Control group received corn oil for ten days. Di-isononyl phthalate treated group received DIP. Di-isononyl phthalate + fish oil treated group received both DIP and FO. FO was found to preserve the histological architecture, tight junction and cell cycle of the colon. In conclusion, the current study provided an evidence that FO has a protective potential against DIP further examinations to be done to fully understand the molecular basis of this potential as a step for further clinical applications.

邻苯二甲酸二异壬酯 (DIP) 被认为是常用的邻苯二甲酸酯的高分子量亚型，很容易影响胃肠道 (GIT)。二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 是鱼油 (FO) 的主要活性成分，其抗炎潜力先前已被证实。目前的研究旨在调查鱼油对白化 Wistar 大鼠结肠 DIP 暴露影响的保护潜力。 60只白化Wistar大鼠分为对照组，接受玉米油十天。邻苯二甲酸二异壬酯治疗组接受DIP。邻苯二甲酸二异壬酯+鱼油治疗组同时接受DIP和FO。 FO被发现可以保留结肠的组织学结构、紧密连接和细胞周期。总之，当前的研究提供了证据，表明 FO 对 DIP 具有保护潜力，需要进行进一步检查，以充分了解这种潜力的分子基础，作为进一步临床应用的一步。