Abstract

The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to be administered orally for the treatment of breast cancer. The loaded DOX and entrapment efficiency reached 64% and 99%, respectively. The results of MWCNTs@MS@CS@DOX confirmed its efficiency as pH-based drug delivery for oral breast cancer therapy.

摘要

阿霉素 (DOX) 的非特异性及其口服生物利用度是临床环境中的主要障碍。本研究基于pH值的变化，首次设计了一种新型纳米基体；涂有介孔二氧化硅（MS）和壳聚糖（CS）的多壁碳纳米管（MWCNT）。后者具有独特的纳米结构，在 DOX 释放中具有 pH 敏感性，可口服用于治疗乳腺癌。负载的 DOX 和包埋效率分别达到 64% 和 99%。MWCNTs@MS@CS@DOX 的结果证实了其作为基于 pH 的药物递送用于口腔乳腺癌治疗的有效性。