Analogs of imine resveratrol alleviate oxidative stress-induced neurotoxicity in PC12 cells via activation of Nrf2,FEBS Open Bio

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Analogs of imine resveratrol alleviate oxidative stress-induced neurotoxicity in PC12 cells via activation of Nrf2
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-05-31 , DOI: 10.1002/2211-5463.13209
Yin Zhang ₁ , Zhixiong Wang ₁ , Jiehong Yang ₁ , Yu He ₁ , Haitong Wan ₁ , Chang Li ₁

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Oxidative stress is closely associated with neurodegenerative, cardiovascular and metabolic diseases. Resveratrol and related compounds have shown great potential as antioxidants via either direct scavenging of abundant reactive oxygen species (ROS) or activation of the Kelch-like ECH-associated protein 1-nuclear factor (erythroid-derived 2)-like 2-antioxidant response elements pathway. In the present study, we evaluated imine resveratrol analogs (IRAs) for their neuroprotective effects against ROS in PC12 cells, which are a commonly employed model system for studies of neuronal development and function. We identified that IRA-3 (4-[[(4-hydroxyphenyl)methylene]amino]-phenol) was more potent than resveratrol at rescuing PC12 cells from H₂O₂-induced oxidative damage, exhibiting a recovery percentage of 60.4% at 50 μm. Our findings suggest that the neuroprotective effect of IRA-3 was achieved via multiple routes, including direct scavenging of ROS, rescue of endogenous antioxidants and activation of the Kelch-like ECH-associated protein 1-nuclear factor (erythroid-derived 2)-like 2-antioxidant response elements pathway. Our results suggest that IRA-3 may have potential for development into a possible treatment for neurodegenerative diseases.

中文翻译：

亚胺白藜芦醇类似物通过激活 Nrf2 减轻 PC12 细胞中氧化应激诱导的神经毒性

氧化应激与神经退行性疾病、心血管疾病和代谢疾病密切相关。白藜芦醇和相关化合物通过直接清除丰富的活性氧 (ROS) 或激活 Kelch 样 ECH 相关蛋白 1-核因子（红细胞衍生 2）样 2-抗氧化反应元件，显示出作为抗氧化剂的巨大潜力途径。在本研究中，我们评估了亚胺白藜芦醇类似物 (IRAs) 对 PC12 细胞中 ROS 的神经保护作用，PC12 细胞是研究神经元发育和功能的常用模型系统。_{我们发现 IRA-3（4-[[(4-羟基苯基）亚甲基]氨基]-苯酚）在从 H 2} O ₂中拯救 PC12 细胞方面比白藜芦醇更有效诱导的氧化损伤，在 50 μm处表现出 60.4% 的恢复百分比。我们的研究结果表明，IRA-3 的神经保护作用是通过多种途径实现的，包括直接清除 ROS、拯救内源性抗氧化剂和激活 Kelch 样 ECH 相关蛋白 1-核因子（红细胞衍生 2）样2-抗氧化反应元件途径。我们的结果表明 IRA-3 可能有潜力发展成为神经退行性疾病的治疗方法。

更新日期：2021-08-03

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