The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.

使用我们开发的酒精性心肌病转化大鼠模型研究了法博莫唑的心脏保护作用的分子机制。结果表明，对酒精性心肌病动物腹腔注射法博莫唑 (15 mg/kg) 28 天有助于调节蛋白 СаМ ( p =0.00001)、Ерас1 ( p =0.021) 和左心室心肌中的Ерас2 ( p =0.018) 和受体 RyR2 ( p =0.0031) 和 IP3R2 ( p =0.006) 在对照动物中增强 ( p<0.05)。这些变化伴随着超声心动图记录的左心室重塑程度的降低和其正性肌力功能的改善。