当前位置: X-MOL 学术J. Pediatr. Adolesc. Gynecol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Multidisciplinary Clinical Considerations in the Treatment of Pediatric Epithelial Ovarian Cancer
Journal of Pediatric and Adolescent Gynecology ( IF 1.7 ) Pub Date : 2021-05-29 , DOI: 10.1016/j.jpag.2021.05.009
Christine M Pennesi 1 , Monica W Rosen 1 , Carrie A McIlwain 1 , Erika A Newman 2 , R Kevin Reynolds 1 , Elisabeth H Quint 1
Affiliation  

Background

Epithelial ovarian cancers are a rare subset of the less than 1% of ovarian cancers diagnosed in children. This case highlights considerations when caring for these patients.

Case

Evaluation of a 12-year-old postmenarchal girl who presented with suprapubic pain revealed a solid/cystic pelvic mass involving bilateral adnexa and elevated Cancer Antigen 125 (CA-125) level. Diagnostic laparoscopy pathology confirmed low-grade papillary serous ovarian carcinoma. Treatment involved surgical tumor debulking, hysterectomy, bilateral salpingo-oophorectomy, and omentectomy; adjuvant chemotherapy with no residual disease, and normalization of Cancer Antigen 125 (CA-125) level; and an aromatase inhibitor for maintenance.

Summary and Conclusion

In children with adult-type gynecologic cancers necessitating treatments including surgical sterilization and hormone-modulating therapy, psychological support and developmentally informed collaboration between adult and pediatric services is essential. Clinical decisions for long-term bone and sexual health present opportunities for future research.



中文翻译:

小儿上皮性卵巢癌治疗中的多学科临床考虑

背景

在儿童诊断出的不到 1% 的卵巢癌中,上皮性卵巢癌是一个罕见的子集。这个案例突出了照顾这些患者时的注意事项。

案子

对一名出现耻骨上疼痛的 12 岁月经后女孩的评估显示,盆腔实性/囊性肿块涉及双侧附件和癌症抗原 125 (CA-125) 水平升高。诊断性腹腔镜病理证实为低级别乳头状浆液性卵巢癌。治疗包括手术切除肿瘤、子宫切除术、双侧输卵管卵巢切除术和网膜切除术;辅助化疗,无残留病灶,癌症抗原 125 (CA-125) 水平正常化;以及用于维护的芳香酶抑制剂。

总结与结论

对于患有成人型妇科癌症的儿童,需要进行手术绝育和激素调节治疗等治疗,心理支持以及成人和儿科服务之间的知情合作是必不可少的。长期骨骼和性健康的临床决策为未来的研究提供了机会。

更新日期:2021-05-29
down
wechat
bug