Objective

In brain volume assessment with MR imaging, it is of interest to know the effects of the pulse sequence and software used, to determine whether they provide equivalent data. The aim of this study was to compare cross-sectional volumes of subcortical and ventricular structures and their repeatability derived from MP2RAGE and MPRAGE images using MorphoBox, and FIRST or ALVIN.

Materials and methods

MPRAGE and MP2RAGE T1-weighted images were obtained from 24 healthy volunteers. Back-to-back scans were performed in 12 of them. Volumes, coefficients of variation, concordance, and correlations were determined.

Results

Significant differences were found for volumes derived from MorphoBox and FIRST. Ventricular volumes determined by MorphoBox and ALVIN were similar. Differences between volumes obtained using MPRAGE and MP2RAGE were significant for a few regions. Coefficients of variation, ranged from 0.2 to 9.1%, showed a significant inverse correlation with the mean volume. There was a correlation between volume measures, but agreement was rated as poor for most regions.

Conclusion

MP2RAGE sequences and MorphoBox are valid options for assessing subcortical and ventricular volumes, in the same way as MPRAGE and FIRST or ALVIN, accepted tools for clinical research. However, caution is needed when comparing volumes obtained with different tools.

中文翻译：

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使用不同脑形态测量软件对 MPRAGE 和 MP2RAGE 图像衍生的皮层下和心室体积进行定量比较

客观的

在使用 MR 成像进行脑容量评估时，了解所使用的脉冲序列和软件的影响，以确定它们是否提供等效数据是很有意义的。本研究的目的是比较皮质下和心室结构的横截面体积及其从使用 MorphoBox 和 FIRST 或 ALVIN 的 MP2RAGE 和 MPRAGE 图像得出的可重复性。

材料和方法

MPRAGE 和 MP2RAGE T1 加权图像来自 24 名健康志愿者。其中12个进行了背靠背扫描。确定了体积、变异系数、一致性和相关性。

结果

来自 MorphoBox 和 FIRST 的体积存在显着差异。由 MorphoBox 和 ALVIN 确定的心室容积相似。使用 MPRAGE 和 MP2RAGE 获得的体积之间的差异在一些地区是显着的。变异系数在 0.2% 到 9.1% 之间，与平均体积呈显着负相关。体积测量之间存在相关性，但大多数地区的一致性被评为差。

结论

MP2RAGE 序列和 MorphoBox 是评估皮层下和心室容积的有效选择，与 MPRAGE 和 FIRST 或 ALVIN 一样，是公认的临床研究工具。但是，在比较使用不同工具获得的体积时需要谨慎。