Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function,BioEssays

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Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function
BioEssays ( IF 3.2 ) Pub Date : 2021-05-29 , DOI: 10.1002/bies.202100092
Michael Briese ₁ , Michael Sendtner ₁

Affiliation

The noncoding RNA 7SK is a critical regulator of transcription by adjusting the activity of the kinase complex P-TEFb. Release of P-TEFb from 7SK stimulates transcription at many genes by promoting productive elongation. Conversely, P-TEFb sequestration by 7SK inhibits transcription. Recent studies have shown that 7SK functions are particularly important for neuron development and maintenance and it can thus be hypothesized that 7SK is at the center of many signaling pathways contributing to neuron function. 7SK activates neuronal gene expression programs that are key for terminal differentiation of neurons. Proteomics studies revealed a complex protein interactome of 7SK that includes several RNA-binding proteins. Some of these novel 7SK subcomplexes exert non-canonical cytosolic functions in neurons by regulating axonal mRNA transport and fine-tuning spliceosome production in response to transcription alterations. Thus, a picture emerges according to which 7SK acts as a multi-functional RNA scaffold that is integral for neuron homeostasis.

中文翻译：

保持平衡：非编码 RNA 7SK 作为神经元发育和功能的主要调节器

通过调节激酶复合物 P-TEFb 的活性，非编码 RNA 7SK 是转录的关键调节因子。从 7SK 释放 P-TEFb 通过促进生产性延伸刺激许多基因的转录。相反，7SK 对 P-TEFb 的螯合会抑制转录。最近的研究表明，7SK 的功能对于神经元的发育和维持特别重要，因此可以假设 7SK 是许多有助于神经元功能的信号通路的中心。7SK 激活神经元基因表达程序，这是神经元终末分化的关键。蛋白质组学研究揭示了 7SK 的复杂蛋白质相互作用组，其中包括几种 RNA 结合蛋白。这些新型 7SK 亚复合体中的一些通过调节轴突 mRNA 转运和微调剪接体的产生来响应转录改变，从而在神经元中发挥非典型的细胞质功能。因此，出现了一幅图，根据该图，7SK 充当了神经元稳态不可或缺的多功能 RNA 支架。

更新日期：2021-07-23

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