This study aimed to determine the cause behind the outbreak of nosocomial adenoviral conjunctivitis in the Neonatal Intensive Care Unit (NICU) and the impact of infection control measures. The objectives of the present study include investigation of the hospital-borne infection associated with adenoviral conjunctivitis, analysis of the possible risk factors, setting bundle infection control measures, which were adjusted according to the control effect. The present study also aims to observe the effect of different intervention measures on controlling adenoviral conjunctivitis. During the first and second intervention periods, overall 635 and 597 NICU patients were enrolled, respectively. Ophthalmoscopy was conducted among 188 (in the first intervention) and 184 (in the second intervention) patients (P>0.05). The times of ophthalmoscopy the patients received were 417 and 457 (P<0.001). During the first intervention, 13 patients suffered from adenoviral conjunctivitis, while no patients with adenoviral conjunctivitis were found during the second intervention (P<0.001). All adenoviral conjunctivitis cases were reported 6-27 days (mean 12 days) after ophthalmoscopy. The hydrogen peroxide disinfection bundle measures can effectively restrict the prevalence of adenoviral conjunctivitis associated with ophthalmoscopy in premature infants.

本研究旨在确定新生儿重症监护室 (NICU) 院内腺病毒性结膜炎爆发的原因以及感染控制措施的影响。本研究的目的包括调查腺病毒性结膜炎相关的医院传播感染情况，分析可能的危险因素，制定捆绑感染控制措施，并根据控制效果进行调整。本研究还旨在观察不同干预措施对控制腺病毒性结膜炎的效果。在第一次和第二次干预期间，总共分别招募了 635 名和 597 名 NICU 患者。对 188 名（第一次干预）和 184 名（第二次干预）患者进行了检眼镜检查（P>0.05）。患者接受检眼镜检查次数分别为417次和457次（P<0.001）。第一次干预期间，13例患者出现腺病毒性结膜炎，第二次干预期间未发现腺病毒性结膜炎患者（P<0.001）。所有腺病毒性结膜炎病例均在检眼镜检查后 6-27 天（平均 12 天）报告。双氧水消毒束措施可有效限制早产儿检眼镜相关腺病毒性结膜炎的患病率。所有腺病毒性结膜炎病例均在检眼镜检查后 6-27 天（平均 12 天）报告。双氧水消毒束措施可有效限制早产儿检眼镜相关腺病毒性结膜炎的患病率。所有腺病毒性结膜炎病例均在检眼镜检查后 6-27 天（平均 12 天）报告。双氧水消毒束措施可有效限制早产儿检眼镜相关腺病毒性结膜炎的患病率。