Acute ischemic stroke (AIS) is the most common neurologic complication of infective endocarditis. We describe a singular case report of a 62- year-old male with AIS related to the occlusion of the left middle cerebral artery. Thrombus-aspiration allowed retrieving a 6 millimeters white thrombus. The real-time polymerase chain reaction performed on the thrombus detected Coxiella Burnetii allowed the diagnosis of infective endocarditis (IE) and the identification of the specific pathogen. Coxiella Burnetii is an endemic, small, intracellular, gram-negative coccobacillus and it is a rare cause of IE. The management of AIS caused by IE remains controversial, although in the cases of major occlusion mechanical thrombectomy is associated with better clinical outcomes. IE patients could not present symptoms and signs related to the infection, therefore we underline the importance of the microbiological analysis of the retrieved thrombi especially when atypical etiology is suspected.

急性缺血性卒中（AIS）是感染性心内膜炎最常见的神经系统并发症。我们描述了一名 62 岁男性患有与左侧大脑中动脉闭塞相关的 AIS 的单一病例报告。血栓抽吸允许取回 6 毫米的白色血栓。对检测到的 Coxiella Burnetii 血栓进行的实时聚合酶链反应允许诊断感染性心内膜炎 (IE) 和鉴定特定病原体。Coxiella Burnetii 是一种地方性小型细胞内革兰氏阴性球杆菌，它是 IE 的罕见病因。由 IE 引起的 AIS 的管理仍然存在争议，尽管在主要闭塞的情况下机械血栓切除术与更好的临床结果相关。IE 患者不能出现与感染相关的症状和体征，