The intestine is a vital organ mediating absorption of nutrients and water. Following tissue damage, the intestine mounts a remarkable regenerative response by reprogramming cellular identity to facilitate reinstatement of homeostasis. Here we review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages. We focus on molecular mechanisms governing reprogramming of cellular identity via epithelial-mesenchymal crosstalk, and how novel approaches in organoid technologies enable identification and characterisation of cell-autonomous repair responses within epithelial cells. Transitioning from the single-cell level to tissue scale, we discuss clonal selection following regeneration and associated pathological repurcussions such as cancer and chronic inflammatory diseases.

肠道是调节营养和水分吸收的重要器官。在组织损伤后，肠道通过重新编程细胞特性来促进体内平衡的恢复，从而产生显着的再生反应。在这里，我们回顾了肠道再生生物学的最新进展和胎儿样重编程的新兴概念，其中成人肠上皮瞬时进入修复相关状态，让人联想到本体论预先存在的阶段。我们专注于通过上皮间充质串扰控制细胞身份重编程的分子机制，以及类器官技术中的新方法如何能够识别和表征上皮细胞内的细胞自主修复反应。从单细胞水平过渡到组织规模，