Gliomas are the main type of intra-axial primary brain tumors. We performed a systematic review of studies on the neutrophil-to-lymphocyte ratio (NLR) and its role in the prognosis of patients with gliomas.

An English-language literature-based search, using the PubMed and Biblioteca Virtual em Saúde databases, was conducted for papers published until May 2, 2020. The quality of the selected articles was stratified using the Newcastle-Ottawa scale’s criteria.

We found 137 publications for a query string. After applying the inclusion criteria, 13 articles were selected. Seven studies assessed overall survival and found high NLR values associated with poor overall survival. Six studies approached the issue of tumor grading and differential diagnosis and demonstrated that patients with high NLR values were diagnosed with high-grade gliomas.

NLR is a low-cost method and an effective prognostic factor associated with tumor grading and OS in patients with gliomas.

神经胶质瘤是轴内原发性脑肿瘤的主要类型。我们对中性粒细胞与淋巴细胞比率 (NLR) 及其在胶质瘤患者预后中的作用进行了系统评价。

使用 PubMed 和 Biblioteca Virtual em Saúde 数据库对发表至 2020 年 5 月 2 日的论文进行了基于英语文献的搜索。使用纽卡斯尔-渥太华量表的标准对所选文章的质量进行分层。

我们为查询字符串找到了 137 个出版物。应用纳入标准后，筛选出 13 篇文章。七项研究评估了总体生存率，发现高 NLR 值与较差的总体生存率相关。六项研究涉及肿瘤分级和鉴别诊断问题，并证明 NLR 值高的患者被诊断为高级别胶质瘤。

NLR 是一种低成本的方法，是与胶质瘤患者的肿瘤分级和 OS 相关的有效预后因素。