A library of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazoles (10a-j) were designed, synthesized and tested for their anticancer activities towards human cancer cell lines such as PC3, DU-145 (prostate cancer), A549 (lung cancer) and MCF-7 (breast cancer) by using MTT method with etoposide as standard drug. Among them, compound 10b showed most promising anticancer activity against PC3, A549, MCF-7, and DU-145 cell lines with IC₅₀ values of 0.01±0.008 µM; 0.45±0.023 µM; 0.081±0.0012 µM and 1.77±0.33 µM.

中文翻译：

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掺入 1,2,4-恶二唑的 1,2,3-三唑-吡唑衍生物作为抗癌剂的合成和生物学评价

设计、合成了 1,2,4-恶二唑并结合 1,2,3-三唑-吡唑 ( 10a - j )的文库，并测试了它们对人类癌细胞系如 PC3、DU-145（前列腺癌）的抗癌活性)、A549 (肺癌) 和 MCF-7 (乳腺癌) 通过使用 MTT 方法以依托泊苷为标准药物。其中，化合物10b对PC3、A549、MCF-7和DU-145细胞系表现出最有前景的抗癌活性，IC ₅₀值为0.01±0.008 μM；0.45±0.023 µM；0.081±0.0012 µM 和 1.77±0.33 µM。