Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership,Yeast

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Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership
Yeast ( IF 2.2 ) Pub Date : 2021-05-28 , DOI: 10.1002/yea.3653
Sabnam Parbin _{1,

2} , Subha Damodharan ₁ , Purusharth I Rajyaguru ₁

Affiliation

Posttranslational modifications play a crucial role in regulating gene expression. Among these modifications, arginine methylation has recently attracted tremendous attention due to its role in multiple cellular functions. This review discusses the recent advances that have established arginine methylation as a major player in determining cytoplasmic messenger RNA (mRNA) fate. We specifically focus on research that implicates arginine methylation in regulating mRNA translation, decay, and RNA granule dynamics. Based on this research, we highlight a few emerging future avenues that will lead to exciting discoveries in this field.

中文翻译：

精氨酸甲基化和细胞质 mRNA 命运：令人兴奋的新伙伴关系

翻译后修饰在调节基因表达中起着至关重要的作用。在这些修饰中，精氨酸甲基化最近因其在多种细胞功能中的作用而引起了极大的关注。本综述讨论了最近的进展，这些进展已将精氨酸甲基化确定为确定细胞质信使 RNA (mRNA) 命运的主要参与者。我们特别关注精氨酸甲基化在调节 mRNA 翻译、衰变和 RNA 颗粒动力学方面的研究。基于这项研究，我们重点介绍了一些新兴的未来途径，这些途径将导致该领域令人兴奋的发现。

更新日期：2021-08-05

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