Background Psychiatric patients are perceived to be especially vulnerable during a pandemic, as it increases stress and uncertainty. Several current publications have considered obsessive-compulsive disorder (OCD) patients to be particularly vulnerable during the coronavirus disease 2019 (COVID-19), and clinicians were advised to adjust treatments accordingly. The purpose of this study was to evaluate the 2- and 6-month impacts of COVID-19 on the symptom severity of OCD patients. Methods A cohort of OCD patients actively treated with Exposure and Response Prevention (ERP) combined with pharmacological treatment was evaluated as part of their regular psychiatric assessment twice: 113 patients were evaluated at their 2-month follow-up and 90 patients (from that cohort) were evaluated at their 6-month follow up. Results Obsessive-compulsive symptom deterioration was not present in 84% of the patients at the 2-month follow-up and 96% of the patients at the 6-month follow-up. The results were also replicated in the OCD subgroup that included patients with contamination (washers) and illness obsessions, who were believed to be particularly vulnerable considering their obsessional content. Conclusions OCD patients (including those with obsessions related to contamination and health) who were under active ERP and pharmacological treatment did not experience exacerbated symptoms during COVID-19 at their 2- and 6-month follow-ups.

中文翻译：

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2019 年冠状病毒病 (COVID-19) 期间的强迫症：临床试验中的 2 个月和 6 个月随访

背景 精神病患者被认为在大流行期间特别脆弱，因为它增加了压力和不确定性。目前的一些出版物认为强迫症 (OCD) 患者在 2019 年冠状病毒病 (COVID-19) 期间特别容易受到影响，因此建议临床医生相应地调整治疗方法。本研究的目的是评估 COVID-19 对强迫症患者症状严重程度的 2 个月和 6 个月影响。方法 对一组接受暴露和反应预防 (ERP) 联合药物治疗积极治疗的强迫症患者进行了两次评估，作为他们常规精神病学评估的一部分：113 名患者在 2 个月的随访中进行了评估，90 名患者（来自该队列) 在他们 6 个月的随访中进行了评估。结果 84% 的患者在 2 个月的随访中和 96% 的患者在 6 个月的随访中没有出现强迫症状恶化。结果也在强迫症亚组中得到了复制，其中包括有污染（洗衣机）和疾病强迫症的患者，考虑到他们的强迫症内容，他们被认为特别容易受到伤害。结论 接受主动 ERP 和药物治疗的强迫症患者（包括那些对污染和健康有强迫症的患者）在 2 个月和 6 个月的随访中在 COVID-19 期间没有出现症状加重。结果也在强迫症亚组中得到了复制，其中包括有污染（洗衣机）和疾病强迫症的患者，考虑到他们的强迫症内容，他们被认为特别容易受到伤害。结论 接受主动 ERP 和药物治疗的强迫症患者（包括那些对污染和健康有强迫症的患者）在 2 个月和 6 个月的随访中在 COVID-19 期间没有出现症状加重。结果也在强迫症亚组中得到了复制，其中包括有污染（洗衣机）和疾病强迫症的患者，考虑到他们的强迫症内容，他们被认为特别容易受到伤害。结论 接受主动 ERP 和药物治疗的强迫症患者（包括那些对污染和健康有强迫症的患者）在 2 个月和 6 个月的随访中在 COVID-19 期间没有出现症状加重。