Oral cancer is highly prevalent in India and is the most frequent cancer type among Indian males. It is also very common in southeast Asia. India has participated in the International Cancer Genome Consortium (ICGC) and some national initiatives to generate large-scale genomic data on oral cancer patients and analyze to identify associations and systematically catalog the associated variants. We have now created an open, web-accessible database of these variants found significantly associated with Indian oral cancer patients, with a user-friendly interface to enable easy mining. We have value added to this database by including relevant data collated from various sources on other global populations, thereby providing opportunities of comparative geographical and/or ethnic analyses. Currently, no other database of similar nature is available on oral cancer. We have developed Database of GENomic Variants of Oral Cancer, a browsable online database framework for storage, retrieval and analysis of large-scale data on genomic variants and make it freely accessible to the scientific community. Presently, the web-accessible database allows potential users to mine data on ∼24 million clinically relevant somatic and germline variants derived from exomes (n = 100) and whole genomes (n = 5) of Indian oral cancer patients; all generated by us. Variant data from The Cancer Genome Atlas and data manually curated from peer-reviewed publications were also incorporated into the database for comparative analyses. It allows users to query the database by a single gene, multiple genes, multiple variant sites, genomic region, patient ID and pathway identities. Database URL: http://research.nibmg.ac.in/dbcares/dbgenvoc/

中文翻译：

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dbGENVOC：口腔癌基因组变异数据库，特别参考印度

口腔癌在印度非常普遍，是印度男性中最常见的癌症类型。在东南亚也很常见。印度参与了国际癌症基因组联盟 (ICGC) 和一些国家倡议，以生成关于口腔癌患者的大规模基因组数据并进行分析以识别关联并系统地编目相关变异。我们现在创建了一个开放的、可通过网络访问的数据库，其中包含与印度口腔癌患者显着相关的这些变体，并具有易于挖掘的用户友好界面。我们通过包括从其他全球人口的各种来源整理的相关数据为该数据库增加了价值，从而提供了比较地理和/或种族分析的机会。现在，没有其他类似性质的关于口腔癌的数据库。我们开发了口腔癌基因组变异数据库，这是一个可浏览的在线数据库框架，用于存储、检索和分析关于基因组变异的大规模数据，并使科学界可以免费访问。目前，可通过网络访问的数据库允许潜在用户挖掘来自印度口腔癌患者外显子组（n = 100）和全基因组（n = 5）的约 2400 万个临床相关体细胞和生殖系变异的数据；都是我们产生的。来自癌症基因组图谱的变异数据和从同行评审出版物中手动整理的数据也被纳入数据库进行比较分析。它允许用户通过单个基因、多个基因、多个变异位点、基因组区域、患者 ID 和通路身份。数据库网址：http://research.nibmg.ac.in/dbcares/dbgenvoc/