Coronary stents are deployed to treat the coronary artery disease (CAD) by reopening stenotic regions in arteries to restore blood flow, but the risk of the in-stent restenosis (ISR) is high after stent implantation. One of the reasons is that stent implantation induces changes in local hemodynamic environment, so it is of vital importance to study the blood flow in stented arteries. Based on regarding the red blood cell (RBC) as a rigid solid particle and regarding the blood (including RBCs and plasma) as particle suspensions, a non-Newtonian particle suspensions model is proposed to simulate the realistic blood flow in this work. It considers the blood’s flow pattern and non-Newtonian characteristic, the blood cell-cell interactions, and the additional effects owing to the bi-concave shape and rotation of the RBC. Then, it is compared with other four common hemodynamic models (Newtonian single-phase flow model, Newtonian Eulerian two-phase flow model, non-Newtonian single-phase flow model, non-Newtonian Eulerian two-phase flow model), and the comparison results indicate that the models with the non-Newtonian characteristic are more suitable to describe the realistic blood flow. Afterwards, based on the non-Newtonian particle suspensions model, the local hemodynamic environment in stented arteries is investigated. The result shows that the stent strut protrusion into the flow stream would be likely to produce the flow stagnation zone. And the stent implantation can make the pressure gradient distribution uneven. Besides, the wall shear stress (WSS) of the region adjacent to every stent strut is lower than 0.5 Pa, and along the flow direction, the low-WSS zone near the strut behind is larger than that near the front strut. What’s more, in the regions near the struts in the proximal of the stent, the RBC particle stagnation zone is easy to be formed, and the erosion and deposition of RBCs are prone to occur. These hemodynamic analyses illustrate that the risk of ISR is high in the regions adjacent to the struts in the proximal and the distal ends of the stent when compared with struts in other positions of the stent. So the research can provide a suggestion on the stent design, which indicates that the strut structure in these positions of a stent should be optimized further.

冠状动脉支架通过重新打开动脉中的狭窄区域以恢复血流来治疗冠状动脉疾病（CAD），但支架植入后支架内再狭窄（ISR）的风险很高。原因之一是支架植入会引起局部血流动力学环境的变化，因此研究支架内动脉的血流具有至关重要的意义。基于将红细胞（RBC）视为刚性固体颗粒，将血液（包括红细胞和血浆）视为颗粒悬浮液，提出了一种非牛顿颗粒悬浮液模型来模拟本工作中的真实血流。它考虑了血液的流动模式和非牛顿特性、血细胞-细胞相互作用以及由于红细胞的双凹形状和旋转而产生的附加效应。然后，与其他四种常见的血流动力学模型（牛顿单相流模型、牛顿欧拉两相流模型、非牛顿单相流模型、非牛顿欧拉两相流模型）进行比较，比较结果表明表明具有非牛顿特征的模型更适合描述真实的血流。然后，基于非牛顿粒子悬浮模型，研究了支架动脉的局部血流动力学环境。结果表明，支架支柱突出到流动流中可能会产生流动停滞区。并且支架植入会使压力梯度分布不均匀。此外，每个支架支柱相邻区域的壁面剪应力（WSS）均低于0.5 Pa，并且沿流动方向，后支柱附近的低 WSS 区大于前支柱附近的低 WSS 区。而且，在支架近端靠近支柱的区域，容易形成红细胞颗粒滞留区，容易发生红细胞的侵蚀和沉积。这些血流动力学分析表明，与支架其他位置的支柱相比，支架近端和远端支柱附近区域发生 ISR 的风险较高。因此，该研究可为支架设计提供建议，表明支架这些位置的支柱结构应进一步优化。并且容易发生红细胞的侵蚀和沉积。这些血流动力学分析表明，与支架其他位置的支柱相比，支架近端和远端支柱附近区域发生 ISR 的风险较高。因此，该研究可为支架设计提供建议，表明支架这些位置的支柱结构应进一步优化。并且容易发生红细胞的侵蚀和沉积。这些血流动力学分析表明，与支架其他位置的支柱相比，支架近端和远端支柱附近区域发生 ISR 的风险较高。因此，该研究可为支架设计提供建议，表明支架这些位置的支柱结构应进一步优化。