Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma,Environmental Science & Technology Letters

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Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2021-05-28 , DOI: 10.1021/acs.estlett.1c00210
Garthika Navaranjan ₁ , Liisa M. Jantunen _{1,

2} , Miriam L. Diamond ₃ , Shelley A. Harris ₁ , Sarah Bernstein ₂ , James A. Scott ₁ , Tim K. Takaro ₄ , Ruixue Dai ₅ , Diana L. Lefebvre ₆ , Piush J. Mandhane ₇ , Theo J. Moraes _{1,

5} , Elinor Simons ₈ , Stuart E. Turvey ₉ , Malcolm R. Sears ₆ , Padmaja Subbarao _{1,

5} , Jeffrey R. Brook ₁

Affiliation

We investigated the association between exposure to 29 organophosphate esters (OPEs) and the onset of childhood asthma and recurrent wheeze. Using a case-cohort design nested in the Canadian CHILD Cohort Study, we included a random sample of children (n = 429), all children with asthma at 5 years (n = 128), and all children with recurrent wheeze between 2 and 5 years (n = 331). The association between 14 highly detected OPEs measured in house dust vacuumed when children were 3–4 months of age, including the child’s sleeping environment, and asthma at 5 years and recurrent wheeze between 2 and 5 years was assessed using logistic regression. The most abundant OPEs were TBOEP (median: 45730 ng/g) ≫ TCiPP (6065 ng/g) > TCEP (5260 ng/g) > TPhP (4440 ng/g) > EHDPP (1750 ng/g). Concentrations were higher than those in most other studies worldwide, potentially due to the inclusion of dust from the child’s sleeping area. A 2–4-fold increased odds of asthma was observed across all quartiles of exposure to TBOEP compared to the lowest quartile, including a positive dose–response relationship. Inverse relationships (p < 0.05) were observed with the odds of asthma and recurrent wheeze for 24DiPPDPP, B4tBPPP, tri-m-cresyl phosphate (TmCP), and EHDPP, and between 4tBPDPP and odds of asthma.

中文翻译：

早年接触磷酸三（2-丁氧基乙基）酯 (TBOEP) 与儿童哮喘的发生有关

我们调查了接触 29 种有机磷酸酯 (OPE) 与儿童哮喘和复发性喘息之间的关联。使用嵌套在加拿大儿童队列研究中的病例队列设计，我们纳入了随机样本的儿童 ( n = 429)、所有 5 岁哮喘儿童 ( n = 128) 和所有 2 至 5 岁间反复喘息的儿童年 ( n= 331）。使用逻辑回归评估了在 3-4 个月大时吸尘的室内灰尘中测量的 14 种高度检测 OPE 之间的关联，包括儿童的睡眠环境、5 岁时的哮喘和 2 至 5 岁时的反复喘息。最丰富的 OPE 是 TBOEP（中值：45730 ng/g）≫ TCiPP（6065 ng/g）> TCEP（5260 ng/g）> TPhP（4440 ng/g）> EHDPP（1750 ng/g）。浓度高于世界范围内大多数其他研究中的浓度，这可能是由于包含了来自儿童睡眠区域的灰尘。与最低四分位数相比，在 TBOEP 暴露的所有四分位数中观察到哮喘几率增加了 2-4 倍，包括正剂量反应关系。逆关系 ( p哮喘和复发性哮鸣音为24DiPPDPP，B4tBPPP，三几率观察到<0.05）米-cresyl磷酸盐（TMCP），和EHDPP和之间4tBPDPP和哮喘的几率。

更新日期：2021-07-13

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