Melanoma is a malignant tumor with high metastasis and mortality. Epithelial-mesenchymal transition (EMT) was reported to be involved in the growth and metastasis of melanoma. To investigate these sections further, we showed that E26 transformation specific 1 (ETS1) could regulate growth, metastasis and EMT process of melanoma by regulating microRNA(miR)-16/SRY-related HMG box (SOX) 4 expression.

中文翻译：

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ETS1通过调节miR-16介导的SOX4表达促进黑色素瘤细胞生长、转移和上皮间质转化过程。

黑色素瘤是一种具有高转移性和死亡率的恶性肿瘤。据报道，上皮间质转化（EMT）参与黑色素瘤的生长和转移。为了进一步研究这些切片，我们发现E26转化特异性1（ETS1）可以通过调节microRNA（miR）-16/SRY相关的HMG box（SOX）4的表达来调节黑色素瘤的生长、转移和EMT过程。