Diabetes mellitus (DM), an endocrine disease is characterized by increased level of blood glucose. Diabetes may affect other functions of the body and organs including, renal function and lipid metabolism. Pandanus tectorius (P. tectorius) Parkinson ex Du Roi is a small tree used in folk medicine in treatment of many diseases. Diabetes in rats was induced by intraperitoneal injection of alloxan at a dose of 100 mg/kg body weight for 3 days. Water and ethanol extracts of root, stem and leave of P. tectorius were given to rats at 200 mg/kg body weight at day 3. Rats were sacrificed on day 4 after 12 h fasting. Serum glucose and other biochemical parameters like liver enzymes; [alanine aminotransferases (ALT), aspartate aminotransferases (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)], kidney parameters (urea & creatinine), lipid profile [total cholesterol, HDL and LDL cholesterol and triglycerides] and coronary artery risk index (CRI) were estimated in blood serum. Antioxidant potential, polyphenol content and phytochemical constituents in different parts of P. tectorius were also determined. Results showed that water extract of stem and ethanol extract of root of P. tectorius produced maximum fall in sugar level of alloxan diabetic rats. Extracts of all three plant parts significantly dropped the increased level of urea and creatinine with maximum reduction in creatinine was observed by water extract of root. P.tectorius extracts showed positive effect on liver enzymes and lipid profile by bringing them closer to normal range in comparison to alloxan diabetic control rats. Phytochemical screening indicated presence of flavonoids, alkaloids, tannins and saponin in P. tectorius. In DPPH free radical scavenging test the highest antioxidant potential was found in water extract of roots, while ethanol extract of stem also showed good activity. The study demonstrated that different parts of P.tectorius have potential to attenuate diabetes and diabetes related complications like, liver, kidney dysfunction and lipid metabolism.

中文翻译：

---

露兜树对四氧嘧啶糖尿病大鼠糖尿病、高脂血症、肝肾功能障碍的保护作用

糖尿病 (DM) 是一种内分泌疾病，其特征是血糖水平升高。糖尿病可能影响身体和器官的其他功能，包括肾功能和脂质代谢。Pandanus tectorius (P. tectorius) Parkinson ex Du Roi 是一种用于民间医学治疗多种疾病的小树。通过以 100 mg/kg 体重的剂量腹膜内注射四氧嘧啶 3 天诱导大鼠糖尿病。在第 3 天以 200 mg/kg 体重的剂量给予大鼠根、茎和叶的水和乙醇提取物。第 4 天禁食 12 小时后处死大鼠。血清葡萄糖和其他生化参数，如肝酶；[丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、碱性磷酸酶 (ALP) 和乳酸脱氢酶 (LDH)]、肾脏参数（尿素和肌酐）、在血清中估计血脂谱[总胆固醇、HDL 和 LDL 胆固醇和甘油三酯]和冠状动脉风险指数 (CRI)。还测定了鹤望兰不同部位的抗氧化能力，多酚含量和植物化学成分。结果表明，四氧嘧啶糖尿病大鼠的茎水提物和根部乙醇提取物使四氧嘧啶糖尿病大鼠的糖水平下降幅度最大。所有三个植物部分的提取物都显着降低了尿素和肌酐的增加水平，通过根的水提取物观察到肌酐的最大降低。与异型四氧嘧啶糖尿病大鼠相比，P.tectorius提取物通过使它们更接近正常范围而对肝脏酶和脂质谱显示出积极作用。植物化学筛选表明存在类黄酮、生物碱、丹参中的单宁和皂苷。在DPPH自由基清除试验中，根的水提取物具有最高的抗氧化能力，而茎的乙醇提取物也表现出良好的活性。该研究表明，P.tectorius 的不同部分具有减轻糖尿病和糖尿病相关并发症的潜力，如肝、肾功能障碍和脂质代谢。