Background. Obesity is a crucial risk factor associated with type 2 diabetes mellitus (T2DM). Excessive accumulation of body fat may affect the glycemia control in T2DM. This study investigated the relationship between body fat percentage and time in range (TIR) assessed by continuous glucose monitoring (CGM) during short-term continuous subcutaneous insulin infusion (CSII) therapy in T2DM patients. Method. A total of 85 T2DM patients were recruited in this cross-sectional study. All participants underwent 72 h CGM period during short-term CSII therapy. TIR was defined as the percentage of time spent within the target glucose range of 3.9-10.0 mmol/L. Body composition was measured using bioelectrical impedance analysis (BIA) and overfat was defined as an amount of body fat of at least 25% of total body mass for men or at least 30% for women. Multiple linear regression models were used to evaluate the independent association of body fat percentage with TIR after adjusting for confounding factors. Results. Compared with normal fat T2DM patients, individual with a higher body fat percentage exhibited lower levels of TIR () and higher 72 h mean blood glucose (72 h MBG) () during short-term CSII treatment. The prevalence of overfat assessed by body fat percentage decreased with the ascending TIR tertiles (). Multiple linear regression analysis indicated that body fat percentage was significantly associated with TIR independent of age, gender, diabetes duration, HbA1c, and BMI (). Conclusions. Body fat percentage was significantly associated with TIR in T2DM during short-term CSII therapy. Reduction of body fat may be an important therapeutic target to improve glycemic control in high body fat T2DM patients, who may benefit less from intensive insulin treatment.

中文翻译：

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在 2 型糖尿病的连续皮下胰岛素输注治疗期间通过连续血糖监测产生的身体脂肪百分比与时间范围内的关联

背景。肥胖是与 2 型糖尿病 (T2DM) 相关的重要危险因素。体内脂肪的过度积累可能会影响 T2DM 的血糖控制。本研究调查了 T2DM 患者短期连续皮下胰岛素输注 (CSII) 治疗期间通过连续血糖监测 (CGM) 评估的体脂百分比与范围时间 (TIR) 之间的关系。方法. 该横断面研究共招募了 85 名 T2DM 患者。所有参与者在短期 CSII 治疗期间都接受了 72 小时的 CGM 期。TIR 定义为在 3.9-10.0 mmol/L 的目标葡萄糖范围内花费的时间百分比。使用生物电阻抗分析 (BIA) 测量身体成分，过度肥胖的定义为男性身体脂肪含量至少为总体质量的 25%，女性至少为 30%。在调整混杂因素后，使用多元线性回归模型评估体脂百分比与 TIR 的独立关联。结果。与正常脂肪的 T2DM 患者相比，体脂百分比较高的个体表现出较低的 TIR 水平。)和更高的 72 h 平均血糖 (72 h MBG) ()在短期 CSII 治疗期间。以体脂百分比评估的过度肥胖的流行率随着 TIR 三分位数的上升而下降（）。多元线性回归分析表明，体脂百分比与 TIR 显着相关，与年龄、性别、糖尿病病程、HbA1c 和 BMI 无关。）。 结论。在短期CSII治疗期间，体脂百分比与T2DM中的TIR显着相关。减少体脂可能是改善高体脂 T2DM 患者血糖控制的重要治疗目标，这些患者可能从强化胰岛素治疗中获益较少。