For more than a century, chromatography has been indispensable as a separation method for both analytics and purification. Among the variety of chromatographic techniques, liquid chromatography has a special status owing to its efficiency and versatility, and its status is further enhanced by the continuous improvements of analysers, materials, methods and understanding, all supported by computational approaches. High performance liquid chromatography (HPLC) has always held a special place in pharmaceutical processing, and computational HPLC has been explored since the very early stages of computing, although without having yet reached its full potential. Herein, we provide a comprehensive and critical review of recent developments in designing and operating liquid chromatographic systems, focussing on their modelling approaches and control strategies at large scale.

一个多世纪以来，色谱法一直是分析和纯化中不可或缺的分离方法。在各种色谱技术中，液相色谱因其高效和通用性而具有特殊的地位，并且随着分析仪、材料、方法和理解的不断改进，所有这些都得到计算方法的支持，它的地位得到进一步提升。高效液相色谱 (HPLC) 在药物加工中一直占据着特殊的地位，并且从计算的早期阶段就开始探索计算 HPLC，尽管尚未充分发挥其潜力。在此，我们对设计和操作液相色谱系统的最新发展进行了全面而重要的回顾，